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抗体蛋白
二抗生物素标记 过氧化物酶(HRP)标记 胶体金试剂 FITC荧光标记 RBITC荧光标记 二抗免疫血清 其它荧光标记二抗 藻红蛋白(PE)荧光标记 胶体金(Gold)标记 SAlexa Fluor荧光系列 碱性磷酸酶(AP)标记 别藻蓝蛋白(APC)荧光标记 其它标记 PE标记二抗 DyLight标记二抗 AU标记二抗 Biotin标记二抗 AMCA标记二抗 Texas Red标记二抗 TRITC标记二抗 HRP标记二抗 未标记二抗 Cy标记二抗 AbBox Fluor标记二抗内参抗体 小分子抗体抗体标记试剂盒细菌抗体蛋白病毒包装试剂杂交瘤融合筛选WB、IHC、ELISA相关试剂细胞培养试剂病原微生物抗原抗体假病毒抗体校准品其他抗原抗体标记的标签抗体病理级IHC抗体重组蛋白
- 细胞培养
- 实验耗材
- 仪器设备
- 生化试剂盒
- 小分子试剂
- 基质胶
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斑马鱼产品
订货方式
订货电话：13564444959
订货时间：周一至周五
订货Q Q：79688691
订货邮件：79688691@qq.com
订货时间：周一至周五
订货Q Q：79688691
订货邮件：79688691@qq.com
产品简介
储存与保存
注意事项
产品简介-
货号IM72009
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产品名称CAR (D3W3G) Rabbit monoclonal antibody
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类别抗体产品
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ClonalityMonoclonal
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推荐应用WB,IP,IHC,IF
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反应种属Human
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存储缓冲液Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
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稀释度WB 1:1000,IP 1:100, IHC 1:500, IF 1:200
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预测分子量45-55kDa
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宿主Rabbit
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同种型IgG
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特异性Endogenous
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纯化Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg328 of human CAR protein.
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背景介绍The coxsackie virus and adenovirus receptor (CXADR, CAR) is a highly conserved, single-transmembrane glycoprotein and the primary receptor to mediate cellular attachment and infection of coxsackie B viruses and most adenoviruses (1,2). The CAR protein contains a pair of Ig-like domains within the amino-terminal extracellular domain and a carboxyl-terminal PDZ motif (1). Research studies indicate that CAR is a tight junction protein that associates with the ZO-1 scaffold protein and promotes both cell adhesion and restriction of solute and ion movement between cells (2). Endogenous CAR is targeted to the basolateral plasma membrane by a tyrosine-based basolateral sorting signal and clathrin adaptors AP-1A and AP-1B (3). CAR binds junctional adhesion molecule L (JAML) on epithelial cells and neutrophils where it activates PI3K and downstream MAPK kinases to stimulate epithelial γδ T cell proliferation and increase production of TNFα and keratinocyte growth factor (4-6). As a result, the CAR protein plays a potentially critical role in adenoviral gene therapy, immunity, wound repair, inflammation, and cancer therapy (4-6). Additional studies demonstrate that CAR is essential in regulating squamous carcinoma cell growth (7).
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UniProt IDP78310
储存与保存1.保存：-20℃
2.有效期：1年
注意事项1.我司生产的生化试剂如无特殊标注，基本为非无菌包装，若用于细胞实验，请提前做好预处理。需低温保存的产品，一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
2.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
3.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
4.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。
备注：由于产品信息可能会有优化升级，请以实际收货标签信息为准。
