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NMDAR2A (7J2) Rabbit Monoclonal Antibody  Cite:0    分享

货号： IM35347
复制产品信息
  • 种属：H，M，R
  • 用途：WB
规格:
50µl 100µl
单位:
支
单价:￥1600.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    NMDAR2A (7J2) Rabbit Monoclonal Antibody
  • 别名
    EPND; FESD; GluN2A; GRIN2A; hNR2A; LKS; N methyl D aspartate receptor channel, subunit epsilon 1; N Methyl D Aspartate Receptor Subtype 2A; NMDAR2A; NR2A;
  • 类别
    抗体产品
  • 基因名称
    GRIN2A
  • 蛋白名称
    NMDAR2A
  • Clonality
    Monoclonal
  • 推荐应用
    WB
  • 稀释度
    WB 1:1000-1:2000
  • 反应种属
    Human,Mouse,Rat
  • 存储缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Human Gene ID
    2903
  • Human Swissprot No.
    Q12879
  • 参考分子量
    165kDa
  • 预测分子量
    165kDa
  • 宿主
    Rabbit
  • 同种型
    IgG
  • 细胞定位
    Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q00959}. Cell membrane; Multi-pass membrane protein. Cell junction, synapse {ECO:0000250|UniProtKB:P35436}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250|UniProtKB:Q00959}; Multi-pass membrane protein. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P35436}. Note=Expression at the dendrite cell membrane and at synapses is regulated by SORCS2 and the retromer complex. {ECO:0000250|UniProtKB:P35436}
  • 功能
    Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:8768735, PubMed:26919761, PubMed:26875626, PubMed:28105280). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have lower sensitivity to glutamate and faster deactivation kinetics than channels formed by GRIN1 and GRIN2B (PubMed:26919761, PubMed:26875626). Contributes to the slow phase of excitatory postsynaptic current, long- term synaptic potentiation, and learning (By similarity).
  • 纯化
    Affinity-chromatography
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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