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Tau (Phospho S356) (2A5) Rabbit Monoclonal Antibody  Cite:0    分享

货号： IM37155
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  • 种属：H
  • 用途：WB
规格:
50µl 100µl
单位:
支
单价:￥1200.00
产品简介
储存与保存
注意事项
产品简介
  • 产品货号
    IM37155
  • 纯度
    Affinity-chromatography
  • 别名
    DDPAC; MAPT; MAPTL; MSTD; Mtapt; MTBT1; MTBT2; PHF tau; PPND; pTau; RNPTAU; TAU
  • 产品名称
    Tau (Phospho S356) (2A5) Rabbit Monoclonal Antibody
  • 类别
    抗体产品
  • 基因名称
    MAPT
  • 蛋白名称
    MAPTL, MTBT1, TAU
  • Clonality
    Monoclonal
  • 推荐应用
    WB
  • 反应种属
    Human
  • 存储缓冲液
    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
  • Human Gene ID
    4137
  • Human Swissprot No.
    P10636
  • 免疫原
    A synthetic phosphopeptide corresponding to residues surrounding Ser356 of human Tau
  • 稀释度
    WB 1:1000
  • 参考分子量
    50-80kDa
  • 预测分子量
    79kDa
  • 宿主
    Rabbit
  • 同种型
    IgG
  • 注意事项
    Phospho-Tau (S356) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
  • 组织表达
    Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system
  • 细胞定位
    Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Cell projection, dendrite. Secreted Note=Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components (PubMed:10747907). Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum- Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059).
  • 功能
    Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
储存与保存

Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles.

注意事项

1.我司生产的生化试剂如无特殊标注，基本为非无菌包装，若用于细胞实验，请提前做好预处理。需低温保存的产品，一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

2.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

3.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

4.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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