产品名称

Collagen V α1 (Cleaved Ala1605) Rabbit Polyclonal Antibody

别名

Collagen alpha-1(V) chain

类别

抗体产品

基因名称

COL5A1

蛋白名称

Collagen V α1 (Cleaved-Ala1605)

Clonality

Polyclonal

推荐应用

WB,ELISA

稀释度

WB 1:1000-2000, ELISA 1:5000-20000

反应种属

Human,Rat,Mouse

浓度

1 mg/ml

存储缓冲液

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

Human Gene ID

1289

Human Swissprot No.

P20908

Mouse Gene ID

12831

Mouse Swissprot No.

O88207

Rat Gene ID

85490

Rat Swissprot No.

Q9JI03

免疫原

Synthesized peptide derived from human Collagen V α1 (Cleaved-Ala1605)

特异性

This antibody detects endogenous levels of Human Collagen V α1 (Cleaved-Ala1605, protein was cleaved amino acid sequence between 1605-1606 )

预测分子量

175 202kDa

宿主

Rabbit

同种型

Rabbit,IgG

背景介绍

disease:Defects in COL5A1 are a cause of Ehlers-Danlos syndrome type 1 (EDS1) [MIM:130000]; also known as Ehlers-Danlos syndrome gravis or severe classic type Ehlers-Danlos syndrome. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS1 is the severe form of classic Ehlers-Danlos syndrome.,disease:Defects in COL5A1 are a cause of Ehlers-Danlos syndrome type 2 (EDS2) [MIM:130010]; also known as Ehlers-Danlos syndrome mitis or mild classic type Ehlers Danlos syndrome.,function:Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.,PTM:Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.,PTM:Sulfated on 40% of tyrosines.,similarity:Belongs to the fibrillar collagen family.,similarity:Contains 1 laminin G-like domain.,similarity:Contains 1 TSP N-terminal (TSPN) domain.,subunit:Trimers of two alpha 1(V) and one alpha 2(V) chains in most tissues and trimers of one alpha 1(V), one alpha 2(V), and one alpha 3(V) chains in placenta. Interacts with CSPG4., 细胞定位 Secreted, extracellular space, extracellular matrix . 功能 blood vessel development, eye development, vasculature development, heart morphogenesis, cell motion, plasma membrane organization, cell adhesion, ectoderm development, sensory organ development, heart development,epidermis development, response to wounding, membrane organization, cell migration, biological adhesion,extracellular matrix organization, collagen fibril organization, collagen metabolic process, collagen biosynthetic process, wound healing, spreading of epidermal cells, wound healing, extracellular structure organization, fibril organization, skin development, multicellular organismal metabolic process, multicellular organismal macromolecule metabolic process, integrin biosynthetic process, eye morphogenesis, cell motility, localization of cell, 纯化 The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. 图片 产品详情 文献引用 (0) 产品问答 内容已折叠 相关产品 内容已折叠 最新浏览的产品 Collagen V α1 (Cleaved Ala1605) Rabbit Polyclonal Antibody BD-PC0139 Collagen IV α1 (Cleaved Gly173) Rabbit Polyclonal Antibody BD-PC0138 Collagen I alpha 2 (18H6) Rabbit Monoclonal Antibody RM0135 Collagen II α1 (Cleaved Gln182) Rabbit Polyclonal Antibody BD-PC0137 评论 留言反馈 评论内容： 上传图片： 商品评价： 提交评论 电话咨询 在线咨询 QQ 二维码 自主产品 新上试剂 特色试剂 其它试剂 抗体制备 免疫检测 抗体产品 重组蛋白 PCR扩增 质粒构建 细胞培养 蛋白表达 细胞生物学 病原研究 疫苗研究 诊断原料 代理产品 代理品牌 关于我们 公司简介 荣誉资质 知识产权 加入我们 联系我们 特色服务 蛋白制备技术服务 抗体制备技术服务 抗体检测技术服务 病毒包装技术服务 细胞相关技术服务 新闻资讯 公司动态 产品百科 苏州博奥龙科技有限公司(实验室) 地址：苏州工业园区金鸡湖大道99号苏州纳米城西北区14幢203室 电话：0512-68216582 联系人：刘经理 手机：13584290138 苏州博特龙免疫技术有限公司(商务) 地址：江苏省苏州市相城区漕湖产业园春兴路16号国方六楼601室 电话：0512-68216582 联系人：黄经理 手机：13812794160 所有试剂仅供科研使用,不得用于人体! Copyright © 2023 苏州博特龙免疫技术有限公司 苏ICP备2021013855号-1

细胞定位

Secreted, extracellular space, extracellular matrix .

功能

blood vessel development, eye development, vasculature development, heart morphogenesis, cell motion, plasma membrane organization, cell adhesion, ectoderm development, sensory organ development, heart development,epidermis development, response to wounding, membrane organization, cell migration, biological adhesion,extracellular matrix organization, collagen fibril organization, collagen metabolic process, collagen biosynthetic process, wound healing, spreading of epidermal cells, wound healing, extracellular structure organization, fibril organization, skin development, multicellular organismal metabolic process, multicellular organismal macromolecule metabolic process, integrin biosynthetic process, eye morphogenesis, cell motility, localization of cell,

纯化

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.