热搜词： 生化试剂 血清抗 细胞 pvdf膜 抗体

咨询热线

13564444959

产品中心

当前位置：首页 > 产品中心 > 抗体蛋白 > 一抗
产品中心
订货方式
订货电话：13564444959
订货时间：周一至周五
订货Q Q：79688691
订货邮件：79688691@qq.com
Collagen XI α1 (Cleaved Ala1563) Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM61447
复制产品信息
  • 种属：H，M
  • 用途：WB，ELISA
规格:
50μl 100μl
单位:
支
单价:￥1500.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    Collagen XI α1 (Cleaved Ala1563) Rabbit Polyclonal Antibody
  • 别名
    Collagen alpha-1(XI) chain;COLL6
  • 类别
    抗体产品
  • 基因名称
    COL11A1
  • 蛋白名称
    Collagen XI α1 (Cleaved-Ala1563)
  • Clonality
    Polyclonal
  • 推荐应用
    WB,ELISA
  • 稀释度
    WB 1:1000-2000, ELISA 1:5000-20000
  • 反应种属
    Human,Mouse
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    1301
  • Human Swissprot No.
    P12107
  • Mouse Gene ID
    12814
  • Mouse Swissprot No.
    Q61245
  • Rat Gene ID
    25654
  • Rat Swissprot No.
    P20909
  • 免疫原
    Synthesized peptide derived from human Collagen XI α1 (Cleaved-Ala1563)
  • 特异性
    This antibody detects endogenous levels of Human,Mouse Collagen XI α1 (Cleaved-Ala1563, protein was cleaved amino acid sequence between 1563-1564 )
  • 预测分子量
    165 200kDa
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    alternative products:Additional isoforms seem to exist. There is alternative usage of exon IIA or exon IIB. Transcripts containing exon IIA or IIB are present in cartilage, but exon IIB is preferentially utilized in transcripts from tendon,disease:Defects in COL11A1 are the cause of Marshall syndrome [MIM:154780]. It is an autosomal dominant disorder with ocular, orofacial, auditory and skeletal manifestations. It shares several features with Stickler syndrome, such as midfacial hypoplasia, high myopia, and sensorineural-hearing deficit.,disease:Defects in COL11A1 are the cause of Stickler syndrome type 2 (STL2) [MIM:604841]; also known as Stickler syndrome vitreous type 2. STL2 is an autosomal dominant form of Stickler syndrome, an inherited disorder that associates ocular signs with more or less complete forms of Pierre Robin sequence, bone disorders and sensorineural deafness. Ocular disorders may include juvenile cataract, myopia, strabismus, vitreoretinal or chorioretinal degeneration, retinal detachment, and chronic uveitis. Robin sequence includes an opening in the roof of the mouth (a cleft palate), a large tongue (macroglossia), and a small lower jaw (micrognathia). Bones are affected by slight platyspondylisis and large, often defective epiphyses. Juvenile joint laxity is followed by early signs of arthrosis. The degree of hearing loss varies among affected individuals and may become more severe over time. Syndrome expressivity is variable.,function:May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils.,PTM:Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.,similarity:Belongs to the fibrillar collagen family.,similarity:Contains 1 TSP N-terminal (TSPN) domain.,subunit:Trimers composed of three different chains: alpha 1(XI), alpha 2(XI), and alpha 3(XI). Alpha 3(XI) is a post-translational modification of alpha 1(II). Alpha 1(V) can also be found instead of alpha 3(XI)=1(II).,tissue specificity:Cartilage, placenta and some tumor or virally transformed cell lines. Isoforms using exon IIA or IIB are found in the cartilage while isoforms using only exon IIB are found in the tendon.,
  • 组织表达
    Cartilage, placenta and some tumor or virally transformed cell lines. Isoforms using exon IIA or IIB are found in the cartilage while isoforms using only exon IIB are found in the tendon.
  • 细胞定位
    Secreted, extracellular space, extracellular matrix .
  • 功能
    skeletal system development, cartilage condensation, chondrocyte differentiation, chondrocyte development, heart morphogenesis, proteoglycan metabolic process, cell adhesion, sensory organ development, heart development,muscle organ development, sensory perception, visual perception, sensory perception of sound, glycoprotein metabolic process, detection of external stimulus, detection of abiotic stimulus, response to mechanical stimulus,response to abiotic stimulus, embryonic development ending in birth or egg hatching, striated muscle tissue development, cell-cell adhesion, biological adhesion, extracellular matrix organization, collagen fibril organization, ear morphogenesis, inner ear morphogenesis, chordate embryonic development, extracellular structure organization, ear development, embryonic organ morphogenesis, embryonic organ development, embryonic morphogenesis, embryonic skeletal system morphogenesis, skeletal system morphogenesis, embryonic skeletal system development, tissue morphogenesis, cardiac muscle tissue development, inner ear development, neurological system process, cognition,detection of stimulus involved in sensory perception, detection of mechanical stimulus involved in sensory perception of sound, sensory perception of light stimulus, sensory perception of mechanical stimulus, detection of mechanical stimulus involved in sensory perception, detection of mechanical stimulus, cartilage development, detection of stimulus, cardiac muscle tissue morphogenesis, ventricular cardiac muscle morphogenesis, muscle tissue morphogenesis, muscle tissue development,
  • 纯化
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

备注：由于产品信息可能会有优化升级，请以实际收货标签信息为准。

产品推荐
<