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HSPA5 (2C18) Mouse Monoclonal antibody  Cite:0    分享

货号： IM43635
复制产品信息
  • 种属：H，M，R
  • 用途：WB
规格:
50μl 100μl
单位:
支
单价:￥1600.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    HSPA5 (2C18) Mouse Monoclonal antibody
  • 类别
    抗体产品
  • 基因名称
    GRP78
  • Clonality
    Monoclonal
  • 推荐应用
    WB
  • 稀释度
    WB 1:500
  • 反应种属
    Human,Mouse,Rat
  • 存储缓冲液
    PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% New type preservative N.
  • Uniprot ID
    P11021
  • Gene ID
    NM_005347
  • 免疫原
    Human recombinant protein fragment of Human HSPA5 (NP_005338) produced in Ecoli.
  • 预测分子量
    72.3kDa
  • 宿主
    Mouse
  • 同种型
    IgG1
  • 功能
    The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. This protein localizes to the lumen of the endoplasmic reticulum (ER) where it operates as a typical HSP70 chaperone involved in the folding and assembly of proteins in the ER and is a master regulator of ER homeostasis. During cellular stress, as during viral infection or tumorogenesis, this protein interacts with the transmembrane stress sensor proteins PERK (protein kinase R-like endoplasmic reticulum kinase), IRE1 (inositol-requiring kinase 1), and ATF6 (activating transcription factor 6) where it acts as a repressor of the unfolded protein response (UPR) and also plays a role in cellular apoptosis and senescence. Elevated expression and atypical translocation of this protein to the cell surface has been reported in viral infections and some types of cancer cells. At the cell surface this protein may facilitate viral attachment and entry to host cells. This gene is a therapeutic target for the treatment of coronavirus diseases and chemoresistant cancers. [provided by RefSeq, Jul 2020]
  • 纯化
    Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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