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CHEK2 (CHK2) (6D19) Mouse Monoclonal antibody  Cite:0    分享

货号： IM44288
复制产品信息
  • 种属：H，M，R，Dg
  • 用途：WB，FCM，IP，IHC-P，IHC-F
规格:
50μl 100μl
单位:
支
单价:￥1600.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    CHEK2 (CHK2) (6D19) Mouse Monoclonal antibody
  • 类别
    抗体产品
  • 基因名称
    CHEK2
  • Clonality
    Monoclonal
  • 推荐应用
    FCM,IHC-P,IHC-F,IP,WB
  • 稀释度
    WB 1:1000-2000, IHC-P/IHC-F 1:150, FCM 1:100, IP 2ug/500ul
  • 反应种属
    Human,Dog,Mouse,Rat
  • 存储缓冲液
    PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% New type preservative N.
  • Uniprot ID
    O96017
  • Gene ID
    NM_007194
  • 免疫原
    Full length human recombinant protein of human CHEK2 (NP_009125) produced in HEK293T cell.
  • 预测分子量
    60.7kDa
  • 宿主
    Mouse
  • 同种型
    IgG2b
  • 背景介绍
    In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
  • 纯化
    Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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