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PRKAR1A (PKA regulatory subunit I alpha) (16M13) Mouse Monoclonal antibody  Cite:0    分享

货号： IM46750
复制产品信息
  • 种属：H，M，R
  • 用途：WB，IHC-P，IF-P，IF-F，IF-ICC，IHC-F
规格:
50μl 100μl
单位:
支
单价:￥1600.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    PRKAR1A (PKA regulatory subunit I alpha) (16M13) Mouse Monoclonal antibody
  • 类别
    抗体产品
  • Uniprot ID
    P10644
  • Gene ID
    NM_212472
  • 基因名称
    Protein Kinase A regulatory subunit I alpha
  • Clonality
    Monoclonal
  • 推荐应用
    IF-P,IF-F,IF-ICC,IHC-P,IHC-F,WB
  • 反应种属
    Human,Mouse,Rat
  • 存储缓冲液
    PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% New type preservative N.
  • 免疫原
    Full-length protein expressed in 293T cell transfected with human PRKAR1A expression vector
  • 稀释度
    WB 1:2000, IHC-P/IHC-F 1:50, IF-P/IF-F/IF-ICC 1:100
  • 预测分子量
    43.0kDa
  • 宿主
    Mouse
  • 同种型
    IgG1
  • 背景介绍
    cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Three alternatively spliced transcript variants encoding the same protein have been observed.
  • 纯化
    Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
储存与保存

1. 保存：-20℃，Avoid freeze/thaw cycles

2. 有效期：1年

注意事项

1. 我司生产的生化试剂如无特殊标注，基本为非无菌包装，若用于细胞实验，请提前做好预处理。需低温保存的产品，一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

2. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

3. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

4. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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