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HSPB8/HSP22(2C3)Mouse Monoclonal Antibody  Cite:0    分享

货号： IM47789
复制产品信息
  • 种属：H，M，R
  • 用途：WB
规格:
50μl 100μl
单位:
支
单价:￥1500.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    HSPB8/HSP22(2C3)Mouse Monoclonal Antibody
  • 别名
    HSPB8; CRYAC; E2IG1; HSP22; PP1629; Heat shock protein beta-8; HspB8; Alpha-crystallin C chain; E2-induced gene 1 protein; Protein kinase H11; Small stress protein-like protein HSP22
  • 类别
    抗体产品
  • 基因名称
    HSPB8
  • 蛋白名称
    Heat shock protein beta-8 (HspB8) (Alpha-crystallin C chain) (E2-induced gene 1 protein) (Protein kinase H11) (Small stress protein-like protein HSP22)
  • Clonality
    Monoclonal
  • 推荐应用
    WB
  • 稀释度
    WB 1:1000-2000
  • 反应种属
    Human,Rat,Mouse
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    26353
  • Human Swissprot No.
    Q9UJY1
  • Mouse Swissprot No.
    Q9JK92
  • Rat Swissprot No.
    Q9EPX0
  • 免疫原
    Recombinant Protein of HSPB8/HSP22
  • 特异性
    HSPB8/HSP22 protein detects endogenous levels of HSPB8/HSP22
  • 预测分子量
    22kDa
  • 宿主
    Mouse
  • 背景介绍
    The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008],
  • 组织表达
    Predominantly expressed in skeletal muscle and heart.
  • 细胞定位
    Cytoplasm . Nucleus . Translocates to nuclear foci during heat shock.
  • 功能
    caution:Was reported (PubMed:10833516) to have a protein kinase activity and to act as a Mn(2+)-dependent serine-threonine-specific protein kinase.,disease:Defects in HSPB8 are the cause of Charcot-Marie-Tooth disease type 2L (CMT2L) [MIM:608673]. CMT2L is an axonal form of Charcot-Marie-Tooth disease. Axonal CMT neuropathies are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy.,disease:Defects in HSPB8 are the cause of distal hereditary motor neuronopathy type 2A (HMN2A) [MIM:158590]; also known as distal hereditary motor neuropathy type IIA or spinal Charcot-Marie-Tooth disease IIA. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective impairment of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs.,function:Displays temperature-dependent chaperone activity.,induction:By 17-beta-estradiol.,PTM:Phosphorylated.,similarity:Belongs to the small heat shock protein (HSP20) family.,subunit:Monomer. Interacts with HSPB1.,tissue specificity:Predominantly expressed in skeletal muscle and heart.,
  • 纯化
    The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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