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CREBBP (PT0619) Mouse Monoclonal Antibody  Cite:0    分享

货号： IM65353
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  • 种属：H
  • 用途：WB，ELISA，IF-P，IF-F，IF-ICC
规格:
50μl 100μl
单位:
支
单价:￥1500.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    CREBBP (PT0619) Mouse Monoclonal Antibody
  • 别名
    CBP
  • 类别
    抗体产品
  • 基因名称
    CREBBP
  • 蛋白名称
    CREB-binding protein (EC 2.3.1.48)
  • Clonality
    Monoclonal
  • 推荐应用
    WB,IF-P,IF-F,IF-ICC,ELISA
  • 稀释度
    WB 1:500-2000, IF-P/IF-F/IF-ICC 1:100-500, ELISA 1:1000-5000
  • 反应种属
    Human
  • 浓度
    1 mg/ml
  • 制备方法
    Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    1387
  • Human Swissprot No.
    Q92793
  • Mouse Swissprot No.
    P45481
  • 特异性
    This antibody detects endogenous levels of CREBBP at Human, Predict react with Mouse, Rat
  • 参考分子量
    265kDa
  • 细胞定位
    Cytoplasm. Nucleus. Recruited to nuclear bodies by SS18L1/CREST. In the presence of ALX1 relocalizes from the cytoplasm to the nucleus.
  • 功能
    Acetylates histones, giving a specific tag for transcriptional activation . Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 . Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers . Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) . Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region . Acetylates DDX21, thereby inhibiting DDX21 helicase activity . Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) . Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway .
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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