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TFE3 (PT2169) Mouse Monoclonal Antibody  Cite:0    分享

货号： IM65363
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  • 种属：H(predicted: M, B)
  • 用途：WB，ELISA，IP，IHC-P
规格:
50μl 100μl
单位:
支
单价:￥1100.00
产品简介
储存与保存
注意事项
产品简介
  • 产品货号
    IM65363
  • 产品名称
    TFE3 (PT2169) Mouse Monoclonal Antibody
  • 类别
    抗体产品
  • 基因名称
    TFE3 BHLHE33
  • 蛋白名称
    Transcription factor E3 (Class E basic helix-loop-helix protein 33) (bHLHe33)
  • Clonality
    Monoclonal
  • 推荐应用
    WB,IP,IHC-P,ELISA
  • 反应种属
    Human (predicted: Mouse, Bovin)
  • 浓度
    1 mg/ml
  • 制备方法
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    7030
  • Human Swissprot No.
    P19532
  • Mouse Gene ID
    209446
  • Mouse Swissprot No.
    Q64092
  • 特异性
    This antibody detects endogenous levels of TFE3 at Human, Predict react with Mouse;Rat
  • 稀释度
    WB 1:500-2000, IP 1:50-100, IHC-P 1:200-400
  • 参考分子量
    62kDa
  • 组织表达
    Ubiquitous in fetal and adult tissues.
  • 细胞定位
    Cytoplasm, cytosol . Nucleus . When nutrients are present, phosphorylation by MTOR prevents nuclear translocation and activity (PubMed:22692423, PubMed:30733432). Conversely, inhibition of mTORC1, starvation and lysosomal disruption, promotes dephosphorylation and translocation to the nucleus (PubMed:22692423, PubMed:30733432).
  • 功能
    Transcription factor that acts as a master regulator of lysosomal biogenesis and immune response . Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (By similarity). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFE3 phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation . Upon starvation or lysosomal stress, inhibition of MTOR induces TFE3 dephosphorylation, resulting in nuclear localization and transcription factor activity . In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer . It also binds very well to a USF/MLTF site . May regulate lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 . Acts as a positive regulator of browning of adipose tissue by promoting expression of target genes; mTOR-dependent phosphorylation promotes cytoplasmic retention of TFE3 and inhibits browning of adipose tissue (By similarity). Maintains the pluripotent state of embryonic stem cells by promoting the expression of genes such as ESRRB; mTOR-dependent nuclear exclusion promotes exit from pluripotency (By similarity). Required to maintain the naive pluripotent state of hematopoietic stem cell; mTOR-dependent cytoplasmic retention of TFE3 promotes the exit of hematopoietic stem cell from pluripotency .
储存与保存

-15°C to -25°C/1 year(Do not lower than -25°C)

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1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。

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