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Caspase-1 (PTR1290) Mouse Monoclonal Antibody  Cite:0    分享

货号： IM65381
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  • 种属：H
  • 用途：WB，ELISA，IF-P，IF-F，IF-ICC
规格:
50μl 100μl
单位:
支
单价:￥1500.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    Caspase-1 (PTR1290) Mouse Monoclonal Antibody
  • 别名
    IL1BC;IL1BCE
  • 类别
    抗体产品
  • 基因名称
    CASP1
  • 蛋白名称
    Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]
  • Clonality
    Monoclonal
  • 推荐应用
    WB,IF-P,IF-F,IF-ICC,ELISA
  • 稀释度
    WB 1:500-2000, IF-P/IF-F/IF-ICC 1:100-500, ELISA 1:1000-5000
  • 反应种属
    Human (predicted: Mouse, Rat, Horse, Pig)
  • 浓度
    1 mg/ml
  • 制备方法
    Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    834
  • Human Swissprot No.
    P29466
  • Mouse Gene ID
    12362
  • Mouse Swissprot No.
    P29452
  • 特异性
    This antibody detects endogenous levels of Caspase-1 at Human, Predict react with Mouse, Rat
  • 参考分子量
    45kDa, 35kDa, cleaced isform p10 :10kDa
  • 宿主
    Mouse
  • 组织表达
    Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.
  • 细胞定位
    Cytoplasm . Cell membrane .
  • 功能
    Thiol protease involved in a variety of inflammatory processes by proteolytically cleaving other proteins, such as the precursors of the inflammatory cytokines interleukin-1 beta (IL1B) and interleukin 18 (IL18) as well as the pyroptosis inducer Gasdermin-D (GSDMD), into active mature peptides . Plays a key role in cell immunity as an inflammatory response initiator: once activated through formation of an inflammasome complex, it initiates a pro-inflammatory response through the cleavage of the two inflammatory cytokines IL1B and IL18, releasing the mature cytokines which are involved in a variety of inflammatory processes . Cleaves a tetrapeptide after an Asp residue at position P1 . Also initiates pyroptosis, a programmed lytic cell death pathway, through cleavage of GSDMD . In contrast to cleavage of interleukins IL1B and IL1B, recognition and cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP1 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part . Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive . In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly . ; [Isoform Delta]: Apoptosis inactive. ; [Isoform Epsilon]: Apoptosis inactive.
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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