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NOXO1 Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM48744
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  • 种属：H，M
  • 用途：WB，ELISA
规格:
50μl 100μl
单位:
支
单价:￥1500.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    NOXO1 Rabbit Polyclonal Antibody
  • 别名
    P41NOX;SH3PXD5
  • 类别
    抗体产品
  • 基因名称
    NOXO1
  • 蛋白名称
    NADPH oxidase organizer 1 (NADPH oxidase regulatory protein) (Nox organizer 1) (Nox-organizing protein 1) (SH3 and PX domain-containing protein 5)
  • Clonality
    Polyclonal
  • 推荐应用
    WB,ELISA
  • 稀释度
    WB 1:500-2000, ELISA 1:5000-20000
  • 反应种属
    Human,Mouse
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
  • Human Gene ID
    124056
  • Human Swissprot No.
    Q8NFA2
  • Mouse Swissprot No.
    Q8VCM2
  • 免疫原
    Synthesized peptide derived from human protein . at AA range: 160-240
  • 特异性
    NOXO1 Polyclonal Antibody detects endogenous levels of protein.
  • 预测分子量
    41kDa
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    This gene encodes an NADPH oxidase (NOX) organizer, which positively regulates NOX1 and NOX3. The protein contains a PX domain and two SH3 domains. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012],
  • 组织表达
    Expressed in testis, small and large intestines, liver, kidney and pancreas. Isoform 3 is mainly expressed in colon. Isoform 1 is preferentially expressed in testis.
  • 细胞定位
    [Isoform 3]: Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Isoform 3 associates with the plasma membrane in a lipid-dependent manner (PubMed:12716910).
  • 功能
    developmental stage:Isoform 3 is expressed in fetal liver.,domain:The PX domain mediates lipid-binding, localization to the plasma membrane and is required for NOX1 activation.,domain:The SH3 domains mediate interaction with CYBA/p22phox. Also mediates intramolecular interaction with the proline-rich region.,function:Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.,similarity:Contains 1 PX (phox homology) domain.,similarity:Contains 2 SH3 domains.,subcellular location:Isoform 3 associates with the plasma membrane in a lipid-dependent manner.,subunit:Interacts with NOX1, NOXA1, CYBA/p22phox and NCF2/p67phox.,tissue specificity:Expressed in testis, small and large intestines, liver, kidney and pancreas. Isoform 3 is mainly expressed in colon. Isoform 1 is preferentially expressed in testis.,
  • 纯化
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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