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SFRP4 Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM49766
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  • 种属：H，M，R
  • 用途：WB，ELISA
规格:
50μl 100μl
单位:
支
单价:￥1500.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    SFRP4 Rabbit Polyclonal Antibody
  • 别名
    FRPHE
  • 类别
    抗体产品
  • 基因名称
    SFRP4
  • 蛋白名称
    Secreted frizzled-related protein 4 (sFRP-4) (Frizzled protein, human endometrium) (FrpHE)
  • Clonality
    Polyclonal
  • 推荐应用
    WB,ELISA
  • 稀释度
    WB 1:500-2000, ELISA 1:5000-20000
  • 反应种属
    Human,Rat,Mouse
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
  • Human Gene ID
    6424
  • Human Swissprot No.
    Q6FHJ7
  • Mouse Swissprot No.
    Q9Z1N6
  • Rat Swissprot No.
    Q9JLS4
  • 免疫原
    Synthesized peptide derived from part region of human protein
  • 特异性
    SFRP4 Polyclonal Antibody detects endogenous levels of protein.
  • 预测分子量
    38kDa
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes. Shows moderate to strong expression in ovarian tumors with expression increasing as the tumor stage increases. In ovarian tumors, expression levels are inversely correlated with expression of CTNNB1 (at protein level).
  • 细胞定位
    Secreted . Cytoplasmic in ovarian tumor cells
  • 信号通路
    WNT;WNT-T CELL
  • 功能
    disease:Associated with tumor-induced osteomalacia, a disorder in which there is an increase in renal phosphate excretion and a reduction in serum phosphate levels leading to hyperphosphaturia, hypophosphatemia and rickets.,domain:The FZ domain is involved in binding with Wnt ligands.,function:Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake.,induction:Increased levels in failing myocardium. Up-regulated in several tumor types including ostomalacia-associated tumors and endometrial and breast carcinomas.,similarity:Belongs to the secreted frizzled-related protein (sFRP) family.,similarity:Contains 1 FZ (frizzled) domain.,similarity:Contains 1 NTR domain.,tissue specificity:Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes.,
  • 纯化
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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