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MYCN Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM50643
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  • 种属：H，M，R
  • 用途：WB，ELISA
规格:
50μl 100μl
单位:
支
单价:￥1500.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    MYCN Rabbit Polyclonal Antibody
  • 别名
    BHLHE37;NMYC
  • 类别
    抗体产品
  • 基因名称
    MYCN
  • 蛋白名称
    N-myc proto-oncogene protein (Class E basic helix-loop-helix protein 37) (bHLHe37)
  • Clonality
    Polyclonal
  • 推荐应用
    WB,ELISA
  • 稀释度
    WB 1:500-2000, ELISA 1:5000-20000
  • 反应种属
    Human,Mouse,Rat
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
  • Human Gene ID
    4613
  • Human Swissprot No.
    P04198
  • Mouse Swissprot No.
    P03966
  • Rat Swissprot No.
    Q63379
  • 免疫原
    Synthesized peptide derived from part region of human protein
  • 特异性
    MYCN Polyclonal Antibody detects endogenous levels of protein.
  • 预测分子量
    51kDa
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog(MYCN) Homo sapiens This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014],
  • 组织表达
    Expressed in the neuronal cells of the cerebrum, neuroblastomas and thyroid tumors (at protein level).
  • 细胞定位
    Nucleus
  • 功能
    developmental stage:Expressed during fetal development.,disease:Amplification of the N-MYC gene is associated with a variety of human tumors, most frequently neuroblastoma, where the level of amplification appears to increase as the tumor progresses.,disease:Defects in MYCN are the cause of Feingold syndrome [MIM:164280]; also known as oculodigitoesophagoduodenal syndrome (ODED). Feingold syndrome is characterized by variable combinations of esophageal and duodenal atresias, microcephaly, learning disability and limb malformations. Cardiac and renal malformations, vertebral anomalies, and deafness have also been described.,disease:Defects in MYCN are the cause of microcephaly and digital abnormalities with normal intelligence [MIM:602585].,function:May function as a transcription factor.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as an heterodimer with MAX. Interacts with KDM5A, KDM5B and HUWE1.,
  • 纯化
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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