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NOXA1 Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM50761
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  • 种属：H，M，R
  • 用途：WB，ELISA
规格:
50μl 100μl
单位:
支
单价:￥1500.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    NOXA1 Rabbit Polyclonal Antibody
  • 别名
    P51NOX
  • 类别
    抗体产品
  • 基因名称
    NOXA1
  • 蛋白名称
    NADPH oxidase activator 1 (NOX activator 1) (Antigen NY-CO-31) (NCF2-like protein) (P67phox-like factor) (p51-nox)
  • Clonality
    Polyclonal
  • 推荐应用
    WB,ELISA
  • 稀释度
    WB 1:500-2000, ELISA 1:5000-20000
  • 反应种属
    Human,Rat,Mouse
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
  • Human Gene ID
    10811
  • Human Swissprot No.
    Q86UR1
  • Mouse Swissprot No.
    Q8CJ00
  • Rat Swissprot No.
    A7E3N7
  • 免疫原
    Synthesized peptide derived from part region of human protein
  • 特异性
    NOXA1 Polyclonal Antibody detects endogenous levels of protein.
  • 预测分子量
    52kDa
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],
  • 组织表达
    Widely expressed. Detected in pancreas, liver, kidney, spleen, prostate, small intestine and colon.
  • 细胞定位
    Cytoplasm. Cell membrane. Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.
  • 功能
    developmental stage:Expressed in fetal kidney.,domain:The SH3 domain mediates interaction with NOXO1 and NCF1 and has autoregulatory function.,domain:The TPR repeats mediate interaction with RAC1.,function:Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.,PTM:Interaction with YWHAZ depends on phosphorylation by PKA.,similarity:Belongs to the NCF2/NOXA1 family.,similarity:Contains 1 OPR domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 4 TPR repeats.,subcellular location:Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.,subunit:NOX1, NOXA1, NOXO1, RAC1 and CYBA forms a functional multimeric complex supporting ROS production. Interaction with YWHAZ prevents the interaction of NOXA1 with NOXO1 and RAC1 and its targeting to membranes, hence reducing its ability to activate NOX1.,tissue specificity:Widely expressed. Detected in pancreas, liver, kidney, spleen, prostate, small intestine and colon.,
  • 纯化
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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