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RN5A Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM57507
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  • 种属：H，M
  • 用途：WB
规格:
50μl 100μl
单位:
支
单价:￥1500.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    RN5A Rabbit Polyclonal Antibody
  • 别名
    RNS4
  • 类别
    抗体产品
  • 基因名称
    RNASEL
  • 蛋白名称
    RN5A
  • Clonality
    Polyclonal
  • 推荐应用
    WB
  • 稀释度
    WB 1:500-2000
  • 反应种属
    Human,Mouse
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    6041
  • Human Swissprot No.
    Q05823
  • Mouse Gene ID
    24014
  • Mouse Swissprot No.
    Q05921
  • 免疫原
    Synthesized peptide derived from human RN5A AA range: 248-298
  • 特异性
    This antibody detects endogenous levels of RN5A at Human/Mouse
  • 参考分子量
    82kDa
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Jul 2008],
  • 组织表达
    Highly expressed in spleen and thymus followed by prostate, testis, uterus, small intestine, colon and peripheral blood leukocytes.
  • 细胞定位
    Cytoplasm . Mitochondrion .
  • 功能
    catalytic activity:Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length.,cofactor:Manganese or magnesium. Required for optimal RNA cleavage rates.,disease:Defects in RNASEL may be the cause of susceptibility to hereditary prostate cancer 1 (HPC1) [MIM:176807, 601518].,domain:The nine ankyrin repeats also called 2-5A sensor constitute the 2-5A binding domain.,domain:The protein kinase domain is predicted to be catalytically inactive. It allows the homodimerization.,enzyme regulation:After binding to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) the homodimerization and subsequent activation occurs. Inhibited by RNase L inhibitor.,function:Endoribonuclease, mediator of interferon action, which play a role in mediating resistance to virus infection and apoptosis. Might play a central role in the regulation of mRNA turnover.,induction:By interferons.,similarity:Belongs to the protein kinase superfamily.,similarity:Contains 1 KEN domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 9 ANK repeats.,subunit:Monomer (inactive form) or homodimer.,tissue specificity:Highly expressed in spleen and thymus followed by prostate, testis, uterus, small intestine, colon and peripheral blood leukocytes.,
  • 纯化
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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