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ATG4a Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM63096
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  • 种属：H，M，R
  • 用途：IHC-P，IF-P，IF-F，IF-ICC
规格:
50μl 100μl
单位:
支
单价:￥1500.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    ATG4a Rabbit Polyclonal Antibody
  • 别名
    Cysteine protease ATG4A (EC 3.4.22.-;AUT-like 2 cysteine endopeptidase;Autophagin-2;Autophagy-related cysteine endopeptidase 2;Autophagy-related protein 4 homolog A;hAPG4A);APG4A;AUTL2
  • 类别
    抗体产品
  • 基因名称
    ATG4A
  • 蛋白名称
    Cysteine protease ATG4A (EC 3.4.22.-) (AUT-like 2 cysteine endopeptidase) (Autophagin-2) (Autophagy-related cysteine endopeptidase 2) (Autophagy-related protein 4 homolog A) (hAPG4A)
  • Clonality
    Polyclonal
  • 推荐应用
    IHC-P,IF-P,IF-F,IF-ICC
  • 稀释度
    IHC-P 1:50-300, IF-P/IF-F/IF-ICC 1:50-200
  • 反应种属
    Human,Mouse,Rat
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    115201
  • Human Swissprot No.
    Q8WYN0
  • Mouse Swissprot No.
    Q8C9S8
  • 免疫原
    Recombinant Protein of ATG4a
  • 特异性
    The antibody detects endogenous ATG4a protein
  • 预测分子量
    45kDa
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. [provided by RefSeq, Mar 2016],
  • 组织表达
    Epithelium,Kidney,Ovary,Prostate,Testis,
  • 细胞定位
    Cytoplasm
  • 信号通路
    Regulation of autophagy
  • 功能
    enzyme regulation:Inhibited by N-ethylmaleimide.,function:Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP.,similarity:Belongs to the peptidase C54 family.,tissue specificity:Widely expressed, at a low level, and the highest expression is observed in skeletal muscle and brain. Also detected in fetal liver.,
  • 纯化
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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