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AMPKα2 Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM63017
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  • 种属：H，M，R
  • 用途：WB
规格:
50μl 100μl
单位:
支
单价:￥1500.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    AMPKα2 Rabbit Polyclonal Antibody
  • 别名
    PRKAA2; AMPK; AMPK2; 5'-AMP-activated protein kinase catalytic subunit alpha-2; AMPK subunit alpha-2; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase
  • 类别
    抗体产品
  • 基因名称
    PRKAA2
  • 蛋白名称
    5'-AMP-activated protein kinase catalytic subunit alpha-2
  • Clonality
    Polyclonal
  • 推荐应用
    WB
  • 稀释度
    WB 1:1000-2000
  • 反应种属
    Human,Mouse,Rat
  • 存储缓冲液
    PBS, pH 7.4, containing 0.5%BSA, 0.02% New type preservative N as Preservative and 50% Glycerol.
  • Human Gene ID
    5563
  • Human Swissprot No.
    P54646
  • Mouse Swissprot No.
    Q8BRK8
  • Rat Swissprot No.
    Q09137
  • 免疫原
    Recombinant Protein of AMPKα2
  • 特异性
    The antibody detects endogenous AMPKα2 protein.
  • 预测分子量
    62kDa
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008],
  • 组织表达
    Heart,Skeletal muscle
  • 细胞定位
    Cytoplasm . Nucleus . In response to stress, recruited by p53/TP53 to specific promoters.
  • 信号通路
    Regulation of autophagy;mTOR;Insulin_Receptor;Adipocytokine;Hypertrophic cardiomyopathy (HCM)
  • 功能
    catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Binding of AMP results in allosteric activation, inducing phosphorylation on Thr-172 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39. Also activated by phosphorylation by CAMKK2 triggered by a rise in intracellular calcium ions, without detectable changes in the AMP/ATP ratio.,function:Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Heterotrimer of a catalytic subunit, a beta and a gamma non-catalytic subunits.
  • 纯化
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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