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CEP164 Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM65428
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  • 种属：H
  • 用途：WB
规格:
50μl 100μl
单位:
支
单价:￥1500.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    CEP164 Rabbit Polyclonal Antibody
  • 别名
    KIAA1052;NPHP15
  • 类别
    抗体产品
  • 基因名称
    CEP164
  • 蛋白名称
    Centrosomal protein of 164 kDa (Cep164)
  • Clonality
    Polyclonal
  • 制备方法
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    22897
  • Human Swissprot No.
    Q9UPV0
  • Mouse Swissprot No.
    Q5DU05
  • 特异性
    This antibody detects endogenous levels of CEP164 at Human
  • 预测分子量
    161kDa
  • 组织表达
    Expressed in several cell lines.
  • 细胞定位
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Nucleus. Localizes specifically to very distally located appendage structures on the mature centriole from which initiate PC formation (PubMed:26337392). Persisted at centrioles throughout mitosis. Expressed in chromatin-enriched nuclear fraction of HeLa cells. In response to DNA damage, it translocates to nuclear foci that contain the DNA damage response proteins KAT5/TIP60 and CHEK1. .
  • 功能
    Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1.
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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