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RNase T2 Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM66036
复制产品信息
  • 种属：H，M
  • 用途：WB
规格:
50μl 100μl
单位:
支
单价:￥1500.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    RNase T2 Rabbit Polyclonal Antibody
  • 别名
    RNASE6PL
  • 类别
    抗体产品
  • 基因名称
    RNASET2
  • 蛋白名称
    Ribonuclease T2 (EC 3.1.27.-) (Ribonuclease 6)
  • Clonality
    Polyclonal
  • 推荐应用
    WB
  • 稀释度
    WB 1:500-2000
  • 反应种属
    Human,Mouse
  • 浓度
    1 mg/ml
  • 制备方法
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    8635
  • Human Swissprot No.
    O00584
  • Mouse Gene ID
    100037283
  • Mouse Swissprot No.
    Q9CQ01
  • 特异性
    This antibody detects endogenous levels of RNase T2 at Human, Mouse
  • 预测分子量
    28kDa
  • 宿主
    Rabbit
  • 组织表达
    Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain.
  • 细胞定位
    Secreted . Lysosome lumen . Endoplasmic reticulum lumen . Mitochondrion intermembrane space . Full-length RNASET2 is found in the endoplasmic reticulum while smaller RNASET2 proteolytic products are found in the lysosome fraction. .
  • 功能
    Ribonuclease that plays an essential role in innate immune response by recognizing and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8 . Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides . In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8 . Plays also a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria . Participates as well in degradation of mitochondrion-associated cytosolic rRNAs .
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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