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ZNF207 Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM67942
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  • 种属：H
  • 用途：WB
规格:
50μl 100μl
单位:
支
单价:￥1500.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    ZNF207 Rabbit Polyclonal Antibody
  • 类别
    抗体产品
  • 基因名称
    ZNF207
  • 蛋白名称
    Zinc finger protein 207
  • Clonality
    Polyclonal
  • 推荐应用
    WB
  • 稀释度
    WB 1:500-2000
  • 反应种属
    Human
  • 浓度
    1 mg/ml
  • 制备方法
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    7756
  • Human Swissprot No.
    O43670
  • 特异性
    This antibody detects endogenous levels of ZNF207 at Human
  • 预测分子量
    53kDa
  • 组织表达
    Ubiquitous
  • 细胞定位
    Nucleus . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle . Localizes primarily to the nucleus in interphase, concentrates at kinetochores prior to nuclear envelope breakdown and during early prometaphase, and disappears from kinetochores upon microtubule-binding. .
  • 功能
    Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly . ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks . Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 . Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 . According to another report, the stabilization is independent of the proteasome .
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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