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GATA-4 (phospho Ser262) Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM51323
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  • 种属：H，M，R
  • 用途：WB，ELISA，IF-P，IF-F，IF-ICC
规格:
50μl 100μl
单位:
支
单价:￥1600.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    GATA-4 (phospho Ser262) Rabbit Polyclonal Antibody
  • 别名
    GATA4; Transcription factor GATA-4; GATA-binding factor 4
  • 类别
    抗体产品
  • 基因名称
    GATA4
  • 蛋白名称
    Transcription factor GATA-4
  • Clonality
    Polyclonal
  • 推荐应用
    WB,IF-P,IF-F,IF-ICC,ELISA
  • 稀释度
    WB 1:500-1:2000, IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:5000.Not yet tested in other applications.
  • 反应种属
    Human,Mouse,Rat
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    2626
  • Human Swissprot No.
    P43694
  • Mouse Gene ID
    14463
  • Mouse Swissprot No.
    Q08369
  • Rat Gene ID
    54254
  • Rat Swissprot No.
    P46152
  • 免疫原
    The antiserum was produced against synthesized peptide derived from human GATA4 around the phosphorylation site of Ser262. AA range:228-277
  • 特异性
    Phospho-GATA-4 (S262) Polyclonal Antibody detects endogenous levels of GATA-4 protein only when phosphorylated at S262.
  • 预测分子量
    48kDa
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function, and is necessary for normal testicular development. Mutations in this gene have been associated with cardiac septal defects. Additionally, alterations in gene expression have been associated with several cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015],
  • 组织表达
    Heart,Lung,
  • 细胞定位
    Nucleus
  • 功能
    disease:Defects in GATA4 are the cause of atrial septal defect type 2 (ASD2) [MIM:607941]. ASD2 is a congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria. ASD2 patients show other heart abnormalities including ventricular and atrioventricular septal defects, pulmonary valve thickening or insufficiency of the cardiac valves. ASD2 is not associated with defects in the cardiac conduction system or non-cardiac abnormalities.,function:Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3'. Acts as a transcriptional activator of ANF in cooperation with NKX2-5.,similarity:Contains 2 GATA-type zinc fingers.,subunit:Interacts with ZNF260 (By similarity). Interacts with the homeobox domain of NKX2-5 through its C-terminal zinc finger. Also interacts with JARID2 which represses its ability to activate transcription of ANF. Interacts with NFATC4.,
  • 纯化
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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