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PLCγ2 (Phospho Tyr759) Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM59577
复制产品信息
  • 种属：H，M
  • 用途：WB，ELISA，IHC-P，IF-P，IF-F，IF-ICC
规格:
50μl 100μl
单位:
支
单价:￥1600.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    PLCγ2 (Phospho Tyr759) Rabbit Polyclonal Antibody
  • 别名
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2)
  • 类别
    抗体产品
  • 基因名称
    PLCG2
  • 蛋白名称
    PLCγ2 (Tyr759)
  • Clonality
    Polyclonal
  • 推荐应用
    WB,IF-P,IF-F,IF-ICC,ELISA,IHC-P
  • 稀释度
    WB 1:500-2000, IF-P/IF-F/IF-ICC/ICC 1:50-200, ELISA 1:2000-20000, IHC-P 1:50-200
  • 反应种属
    Human,Mouse
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    5336
  • Human Swissprot No.
    P16885
  • Mouse Gene ID
    234779
  • Mouse Swissprot No.
    Q8CIH5
  • Rat Gene ID
    29337
  • Rat Swissprot No.
    P24135
  • 免疫原
    Synthesized phosho peptide around human PLCγ2 (Tyr759)
  • 特异性
    This antibody detects endogenous levels of Human Mouse PLCγ2 (phospho-Tyr759)
  • 预测分子量
    148kDa
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014],
  • 组织表达
    Lymph,Lymphoblast,Spleen,T-cell,
  • 细胞定位
    intracellular,cytosol,plasma membrane,extracellular exosome,
  • 信号通路
    Inositol phosphate metabolism;ErbB_HER;Calcium;Phosphatidylinositol signaling system;VEGF;Natural killer cell mediated cytotoxicity;B_Cell_Antigen;Fc epsilon RI;Fc gamma R-mediated phagocytosis;Leukocyte transendothelial migration;Neurotrophin;Vibrio cholerae infection;Epithelial cell signaling in Helicobacter pylori infection;Pathways in cancer;Glioma;Non-small cell lung cancer;
  • 功能
    catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.,cofactor:Calcium.,function:The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.,PTM:Phosphorylated on tyrosine residues; upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Increases phospholipase activity.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 PI-PLC X-box domain.,similarity:Contains 1 PI-PLC Y-box domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 SH2 domains.,
  • 纯化
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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