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Chk2 (Phospho Thr432) Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM62707
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  • 种属：H，M，R
  • 用途：WB，ELISA
规格:
50μl 100μl
单位:
支
单价:￥1600.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    Chk2 (Phospho Thr432) Rabbit Polyclonal Antibody
  • 别名
    Serine/threonine-protein kinase Chk2 (EC 2.7.11.1;CHK2 checkpoint homolog;Cds1 homolog;Hucds1;hCds1;Checkpoint kinase 2);CDS1;CHK2;RAD53
  • 类别
    抗体产品
  • 基因名称
    CHEK2
  • 蛋白名称
    Chk2 (Phospho Thr432)
  • Clonality
    Polyclonal
  • 推荐应用
    WB,ELISA
  • 稀释度
    WB 1:1000-2000, ELISA 1:5000-20000
  • 反应种属
    Human,Mouse,Rat
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    11200
  • Human Swissprot No.
    O96017
  • Mouse Gene ID
    50883
  • Mouse Swissprot No.
    Q9Z265
  • 免疫原
    Synthesized peptide derived from human Chk2 (Phospho Thr432)
  • 特异性
    This antibody detects endogenous levels of Human,Mouse,Rat Chk2 (Phospho Thr432)
  • 预测分子量
    60kDa
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,disease:Defects in CHEK2 are associated with Li-Fraumeni syndrome 2 (LFS2) [MIM:609265]; a highly penetrant familial cancer phenotype usually associated with inherited mutations in p53/TP53.,disease:Defects in CHEK2 are found in some patients with osteosarcoma (OSRC) [MIM:259500].,disease:Defects in CHEK2 are found in some patients with prostate cancer (CaP) [MIM:176807].,enzyme regulation:Rapidly phosphorylated on Thr-68 by MLTK in response to DNA damage and to replication block. Kinase activity is also up-regulated by autophosphorylation.,function:Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on 'Ser-216', preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at 'Thr-18' and 'Ser-20'.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHK2 subfamily.,similarity:Contains 1 FHA domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Isoform 10 is present throughout the cell.,tissue specificity:High expression is found in testis, spleen, colon and peripheral blood leukocytes. Low expression is found in other tissues.,
  • 组织表达
    High expression is found in testis, spleen, colon and peripheral blood leukocytes. Low expression is found in other tissues.
  • 细胞定位
    [Isoform 2]: Nucleus. Isoform 10 is present throughout the cell.; [Isoform 4]: Nucleus.; [Isoform 7]: Nucleus.; [Isoform 9]: Nucleus.; [Isoform 12]: Nucleus.; Nucleus, PML body. Nucleus, nucleoplasm. Recruited into PML bodies together with TP53.
  • 功能
    cell cycle checkpoint, DNA damage checkpoint, protein amino acid phosphorylation, phosphorus metabolic process,phosphate metabolic process, induction of apoptosis, response to DNA damage stimulus, cell cycle, intracellular signaling cascade, induction of apoptosis by intracellular signals, DNA damage response, signal transduction resulting in induction of apoptosis, regulation of cell death, positive regulation of cell death, induction of programmed cell death,phosphorylation, DNA integrity checkpoint, cellular response to stress, DNA damage response, signal transduction,regulation of apoptosis, positive regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, regulation of cell cycle,
  • 纯化
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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