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PDHK1 (Phospho Tyr243) Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM62766
复制产品信息
  • 种属：H，M，R
  • 用途：WB，ELISA，IHC-P
规格:
50μl 100μl
单位:
支
单价:￥1600.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    PDHK1 (Phospho Tyr243) Rabbit Polyclonal Antibody
  • 别名
    [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial (EC 2.7.11.2;Pyruvate dehydrogenase kinase isoform 1);PDHK1
  • 类别
    抗体产品
  • 基因名称
    PDK1
  • 蛋白名称
    PDHK1 (Phospho Tyr243)
  • Clonality
    Polyclonal
  • 推荐应用
    WB,ELISA,IHC-P
  • 稀释度
    WB 1:500-2000, IHC-P 1:50-300, ELISA 2000-20000
  • 反应种属
    Human,Mouse,Rat
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    5163
  • Human Swissprot No.
    Q15118
  • Mouse Gene ID
    228026
  • Mouse Swissprot No.
    Q8BFP9
  • Rat Swissprot No.
    Q63065
  • 免疫原
    Synthesized peptide derived from human PDHK1 (Phospho Tyr243)
  • 特异性
    This antibody detects endogenous levels of Human,Mouse,Rat PDHK1 (Phospho Tyr243)
  • 预测分子量
    50kDa
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013],
  • 组织表达
    Expressed predominantly in the heart. Detected at lower levels in liver, skeletal muscle and pancreas.
  • 细胞定位
    Mitochondrion matrix .
  • 功能
    catalytic activity:ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate.,function:Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.,similarity:Belongs to the PDK/BCKDK protein kinase family.,similarity:Contains 1 histidine kinase domain.,tissue specificity:Expressed predominantly in the heart.,
  • 纯化
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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