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ADAMTS-7 Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM52126
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  • 种属：H，M，R
  • 用途：ELISA，IHC-P，IF-P，IF-F，IF-ICC
规格:
50μl 100μl
单位:
支
单价:￥1500.00
产品简介
储存与保存
注意事项
产品简介
  • 产品简介
    ADAMTS-7 Rabbit Polyclonal Antibody
  • 别名
    ADAMTS7; A disintegrin and metalloproteinase with thrombospondin motifs 7; ADAM-TS 7; ADAM-TS7; ADAMTS-7; COMPase
  • 类别
    抗体产品
  • 基因名称
    ADAMTS7
  • 蛋白名称
    A disintegrin and metalloproteinase with thrombospondin motifs 7
  • Clonality
    Polyclonal
  • 推荐应用
    IHC-P,IF-P,IF-F,IF-ICC,ELISA
  • 稀释度
    IHC-P 1:100-1:300, ELISA 1:40000, IF-P/IF-F/IF-ICC 1:50-200
  • 反应种属
    Human,Rat,Mouse
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    11173
  • Human Swissprot No.
    Q9UKP4
  • Mouse Swissprot No.
    Q68SA9
  • 免疫原
    Synthesized peptide derived from ADAMTS-7 . at AA range: 150-230
  • 特异性
    ADAMTS-7 Polyclonal Antibody detects endogenous levels of ADAMTS-7 protein.
  • 参考分子量
    110kDa
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and may regulate vascular smooth muscle cell (VSMC) migration. Mutations in this gene may be associated with susceptibility to coronary artery disease. [provided by RefSeq, Feb 2016],
  • 组织表达
    Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Detected in meniscus, bone, tendon, cartilage, synovium, fat and ligaments.
  • 细胞定位
    Secreted, extracellular space, extracellular matrix . Also found associated with the external cell surface. .
  • 功能
    cofactor:Binds 1 zinc ion per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,domain:The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.,function:Metalloprotease that may play a role in the degradation of COMP.,induction:Up-regulated in articular cartilage and synovium from arthritis patients.,PTM:May be cleaved by a furin endopeptidase (By similarity). The precursor is sequentially processed.,PTM:N-glycosylated.,PTM:O-glycosylated proteoglycan. Contains chondroitin sulfate.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 peptidase M12B domain.,similarity:Contains 1 PLAC domain.,similarity:Contains 8 TSP type-1 domains.,subcellular location:Also found associated with the external cell surface.,subunit:Interacts with COMP.,tissue specificity:Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Detected in meniscus, bone, tendon, cartilage, synovium, fat and ligaments.,
  • 纯化
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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