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Claudin-1 Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM52818
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  • 种属：H，M，R
  • 用途：WB，ELISA，IHC-P，IF-P，IF-F，IF-ICC
规格:
50μl 100μl
单位:
支
单价:￥1500.00
产品简介
储存与保存
注意事项
产品简介
  • 产品货号
    IM52818
  • 别名
    CLDN1; CLD1; SEMP1; Claudin-1; Senescence-associated epithelial membrane protein
  • 产品名称
    Claudin-1 Rabbit Polyclonal Antibody
  • 类别
    抗体产品
  • 基因名称
    CLDN1
  • 蛋白名称
    Claudin-1
  • Clonality
    Polyclonal
  • 推荐应用
    WB,IHC-P,IF-P,IF-F,IF-ICC,ELISA
  • 反应种属
    Human,Mouse,Rat
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    9076
  • Human Swissprot No.
    O95832
  • Mouse Gene ID
    12737
  • Mouse Swissprot No.
    O88551
  • Rat Gene ID
    65129
  • Rat Swissprot No.
    P56745
  • 免疫原
    The antiserum was produced against synthesized peptide derived from human Claudin 1. AA range:162-211
  • 特异性
    Claudin-1 Polyclonal Antibody detects endogenous levels of Claudin-1 protein.
  • 稀释度
    WB 1:500-1:2000, IHC-P 1:100-300, ELISA 1:20000, IF-P/IF-F/IF-ICC 1:100-300, Not yet tested in other applications.
  • 预测分子量
    22kDa
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq, Jul 2008],
  • 组织表达
    Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis.
  • 细胞定位
    Cell junction, tight junction . Cell membrane ; Multi-pass membrane protein . Basolateral cell membrane . Associates with CD81 and the CLDN1-CD81 complex localizes to the basolateral cell membrane.
  • 信号通路
    Cell adhesion molecules (CAMs);Tight junction;Leukocyte transendothelial migration;Pathogenic Escherichia coli infection;
  • 功能
    disease:Defects in CLDN1 are the cause of ichthyosis-sclerosing cholangitis neonatal syndrome (NISCH) [MIM:607626]; also called ichthyosis with leukocyte vacuoles alopecia and sclerosing cholangitis (ILVASC). NISCH is a rare autosomal recessive complex ichthyosis syndrome characterized by scalp hypotrichosis, scarring alopecia, vulgar type ichthyosis, and sclerosing cholangitis.,function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity (By similarity). Acts as a co-receptor for HCV entry into hepatic cells.,similarity:Belongs to the claudin family.,subunit:Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN2, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ and INADL (By similarity). May interact with HCV E1 and E2 proteins.,tissue specificity:Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis.
  • 纯化
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存与保存

1.保存：-20℃
2.有效期：1年

注意事项

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。

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