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FSHR Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM53542
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  • 种属：H，M，R
  • 用途：WB，ELISA，IHC-P，IF-P，IF-F，IF-ICC
规格:
50μl 100μl
单位:
支
单价:￥1400.00
产品简介
储存与保存
注意事项
产品简介
  • 货号
    IM53542
  • 别名
    FSHR; LGR1; Follicle-stimulating hormone receptor; FSH-R; Follitropin receptor
  • 产品名称
    FSHR Rabbit Polyclonal Antibody
  • 类别
    抗体产品
  • 基因名称
    FSHR
  • 蛋白名称
    Follicle-stimulating hormone receptor
  • Clonality
    Polyclonal
  • 推荐应用
    WB,IHC-P,IF-P,IF-F,IF-ICC,ELISA
  • 反应种属
    Human,Mouse,Rat
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    2492
  • Human Swissprot No.
    P23945
  • Mouse Gene ID
    14309
  • Mouse Swissprot No.
    P35378
  • Rat Gene ID
    25449
  • Rat Swissprot No.
    P20395
  • 免疫原
    The antiserum was produced against synthesized peptide derived from human FSHR. AA range:211-260
  • 特异性
    FSHR Polyclonal Antibody detects endogenous levels of FSHR protein.
  • 稀释度
    IHC-P 100-300, WB 1:500-1:2000, ELISA 1:5000, IF-P/IF-F/IF-ICC 1:50-200
  • 预测分子量
    70kDa
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010],
  • 组织表达
    Sertoli cells and ovarian granulosa cells.
  • 细胞定位
    Cell membrane ; Multi-pass membrane protein .
  • 信号通路
    Neuroactive ligand-receptor interaction;
  • 功能
    disease:Defects in FSHR are a cause of ovarian dysgenesis 1 (ODG1) [MIM:233300]; also known as premature ovarian failure or gonadal dysgenesis XX type or XX gonadal dysgenesis (XXGD) or hereditary hypergonadotropic ovarian failure or hypergonadotropic ovarian dysgenesis with normal karyotype. ODG1 is an autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).,disease:Defects in FSHR are a cause of ovarian hyperstimulation syndrome (OHSS) [MIM:608115]. OHSS is a disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis.,function:Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.,online information:Glycoprotein-hormone Receptors Information System,online information:The Singapore human mutation and polymorphism database,PTM:N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone.,similarity:Belongs to the G-protein coupled receptor 1 family.,similarity:Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.,similarity:Contains 10 LRR (leucine-rich) repeats.,tissue specificity:Sertoli cells and ovarian granulosa cells.,
  • 纯化
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存与保存

1.保存：-20℃
2.有效期：1年

注意事项

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