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GluR-δ2 Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM53660
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  • 种属：H，M，R
  • 用途：WB，ELISA，IF-P，IF-F，IF-ICC
规格:
50μl 100μl
单位:
支
单价:￥1500.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    GluR-δ2 Rabbit Polyclonal Antibody
  • 别名
    GRID2; GLURD2; Glutamate receptor delta-2 subunit; GluR delta-2 subunit
  • 类别
    抗体产品
  • 基因名称
    GRID2
  • 蛋白名称
    Glutamate receptor delta-2 subunit
  • Clonality
    Polyclonal
  • 推荐应用
    WB,IF-P,IF-F,IF-ICC,ELISA
  • 稀释度
    WB 1:500-1:2000, IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:20000.Not yet tested in other applications.
  • 反应种属
    Human,Mouse,Rat
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    2895
  • Human Swissprot No.
    O43424
  • Mouse Gene ID
    14804
  • Mouse Swissprot No.
    Q61625
  • Rat Gene ID
    79220
  • Rat Swissprot No.
    Q63226
  • 免疫原
    The antiserum was produced against synthesized peptide derived from human GRID2. AA range:831-880
  • 特异性
    GluR-δ2 Polyclonal Antibody detects endogenous levels of GluR-δ2 protein.
  • 预测分子量
    113kDa
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this
  • 组织表达
    Brain,Cerebellum,PCR rescued clones
  • 细胞定位
    Cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein
  • 信号通路
    Neuroactive ligand-receptor interaction;Long-term depression
  • 功能
    domain:The PDZ-binding motif mediates interaction with GOPC.,function:Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.,similarity:Belongs to the glutamate-gated ion channel (TC 1.A.10) family.,subunit:Interacts with AIP1, AP4M1, BECN1, GOPC, GRID2IP, SHANK1 and SHANK2.
  • 纯化
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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