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mGluR-2/3 Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM54315
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  • 种属：H，M，R
  • 用途：WB，ELISA，IHC-P，IF-P，IF-F，IF-ICC
规格:
50μl 100μl
单位:
支
单价:￥1500.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    mGluR-2/3 Rabbit Polyclonal Antibody
  • 别名
    GRM2; GPRC1B; MGLUR2; Metabotropic glutamate receptor 2; mGluR2; GRM3; GPRC1C; MGLUR3; Metabotropic glutamate receptor 3; mGluR3
  • 类别
    抗体产品
  • 基因名称
    GRM2
  • 蛋白名称
    Metabotropic glutamate receptor 2
  • Clonality
    Polyclonal
  • 推荐应用
    WB,IHC-P,IF-P,IF-F,IF-ICC,ELISA
  • 稀释度
    WB 1:500-1:2000, IHC-P 1:100-1:300, ELISA 1:20000, IF-P/IF-F/IF-ICC 1:50-200
  • 反应种属
    Human,Mouse,Rat
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    2912/2913
  • Human Swissprot No.
    Q14416/Q14832
  • Mouse Gene ID
    108068/108069
  • Rat Gene ID
    24415/24416
  • Rat Swissprot No.
    P31421/P31422
  • 免疫原
    The antiserum was produced against synthesized peptide derived from human mGluR2/3. AA range:823-872
  • 特异性
    mGluR-2/3 Polyclonal Antibody detects endogenous levels of mGluR-2/3 protein.
  • 预测分子量
    100kDa
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    glutamate metabotropic receptor 2(GRM2) Homo sapiens L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene
  • 组织表达
    Detected in brain cortex (at protein level). Widely expressed in different regions of the adult brain as well as in fetal brain.
  • 细胞定位
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse . Cell projection, dendrite .
  • 信号通路
    Neuroactive ligand-receptor interaction
  • 功能
    function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.,similarity:Belongs to the G-protein coupled receptor 3 family.,subunit:Interacts with GRASP.,tissue specificity:Widely expressed in different regions of the adult brain as well as in fetal brain.,
  • 纯化
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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