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MLK3 Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM54355
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  • 种属：H，M，R
  • 用途：WB，IF，IHC-P，IHC-F
规格:
50μl 100μl
单位:
支
单价:￥1300.00
产品简介
储存与保存
注意事项
产品简介
  • 货号
    IM54355
  • 别名
    MEKK11; MGC17114; Mitogen-activated protein kinase kinase kinase 11; Mixed lineage kinase 3; Mixed lineage protein kinase 3; Mlk-3; Mlk3; Protein tyrosine kinase PTK1; PTK1; RHOE; SH3 domain containing proline rich kinase; SPRK; Src-homology 3 domain-containing proline-rich kinase; 2610017K16Rik; EC 2.7.11.25; M3K11_HUMAN.
  • 产品名称
    MLK3 Rabbit Polyclonal Antibody
  • 抗体来源
    Rabbit
  • 克隆类型
    Polyclonal
  • 反应种属
    Human,Mouse,Ra
  • 产品应用
    WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
  • 理论分子量
    93 kDa
  • 细胞定位
    细胞浆
  • 性状
    Liquid
  • 浓度
    1mg/ml
  • 免疫原
    KLH conjugated synthetic peptide derived from human MLK3: 355-460/847
  • 亚型
    IgG
  • 纯化方法
    affinity purified by Protein A
  • 缓冲液
    0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
  • 产品介绍
    Members of the mixed-lineage kinase (MLK) family (including MLK1, MLK2, MLK3, and dual leucine zipper kinase [DLK]) are serine/threonine protein kinases that are expressed in multiple cell types. MLK3 is activated by phosphorylation in response to stress stimuli (e.g., inflammatory responses, UV, chemical stress) that are coupled to the small GTPase, Cdc42/rac. MLK3 is a multifunctional kinase that plays an essential role in several signaling pathways, including mitogen-activated protein kinase (i.e. activation of JNK and p38), IkappaB/NFkappaB, and p70 S6 kinase. Indeed MLK3 signaling occurs through multiple signaling domains in this protein kinase including (from N- to C-terminal) a glycine-rich domain, Src homology 3 (SH3) domain, a kinase domain, a zipper domain, a Cdc42/rac interactive binding (CRIB) domain and a Pro/Ser/Thr-rich domain. Phosphorylation of MLK3 occurs on multiple residues including threonine 277 and serine 281 within the activation loop of the kinase domain.
  • Function
    Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1). Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.
  • Subunit
    Homodimer; undergoes dimerization during activation.
  • Subcellular Location
    Cytoplasm, cytoskeleton, centrosome. Note=Location is cell cycle dependent.
  • Tissue Specificity
    Expressed in a wide variety of normal and neoplastic tissues including fetal lung, liver, heart and kidney, and adult lung, liver, heart, kidney, placenta, skeletal muscle, pancreas and brain.
  • Post-translational modifications
    Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-277 is likely to be the main autophosphorylation site. Phosphorylation of Ser-555 and Ser-556 is induced by CDC42.
  • Similarity
    Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Contains 1 protein kinase domain. Contains 1 SH3 domain.
  • SWISS
    Q6P2G4
  • Gene ID
    4296
储存与保存

1.保存：-20℃
2.有效期：1年

注意事项

1.我司生产的生化试剂如无特殊标注，基本为非无菌包装，若用于细胞实验，请提前做好预处理。需低温保存的产品，一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

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