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NOS2 Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM54675
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  • 种属：H，M，R
  • 用途：WB，ELISA，IHC-P，IF-P，IF-F，IF-ICC
规格:
50μl 100μl
单位:
支
单价:￥1500.00
产品简介
储存与保存
注意事项
产品简介
  • 产品货号
    IM54675
  • 别名
    NOS2; NOS2A; Nitric oxide synthase; inducible; Hepatocyte NOS; HEP-NOS; Inducible NO synthase; Inducible NOS; iNOS; NOS type II; Peptidyl-cysteine S-nitrosylase NOS2;INOS
  • 产品名称
    NOS2 Rabbit Polyclonal Antibody
  • 类别
    抗体产品
  • 基因名称
    NOS2
  • 蛋白名称
    Nitric oxide synthase inducible
  • Clonality
    Polyclonal
  • 推荐应用
    IF-P,IF-F,IF-ICC,WB,IHC-P,ELISA
  • 反应种属
    Human,Mouse,Rat
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    4843
  • Human Gene Link
    http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4843
  • Human Swissprot No.
    P35228
  • Human Swissprot Link
    http://www.uniprot.org/uniprotkb/P35228/entry
  • Mouse Gene ID
    18126
  • Mouse Gene Link
    http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18126
  • Mouse Swissprot No.
    P29477
  • Mouse Swissprot Link
    http://www.uniprot.org/uniprot/P29477
  • Rat Gene ID
    24599
  • Rat Gene Link
    http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24599
  • Rat Swissprot No.
    Q06518
  • Rat Swissprot Link
    http://www.uniprot.org/uniprot/Q06518
  • 免疫原
    The antiserum was produced against synthesized peptide derived from human iNOS. AA range:117-166
  • 特异性
    NOS2 Polyclonal Antibody detects endogenous levels of NOS2 protein.
  • 稀释度
    IF-P/IF-F/IF-ICC 1:50-200, WB 1:500-2000, ELISA 1:10000-20000, IHC-P 1:50-300
  • 预测分子量
    131kDa
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008],
  • 组织表达
    Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets. Expressed in chondrocytes (PubMed:7504305).
  • 细胞定位
    Cytoplasm, cytosol . Localizes as discrete foci scattered throughout the cytosol and in the presence of SPSB1 and SPSB4, exhibits a more diffuse cytosolic localization. .
  • 信号通路
    Arginine and proline metabolism;Calcium;Pathways in cancer;Small cell lung cancer;
  • 功能
    catalytic activity:L-arginine + n NADPH + n H(+) + m O(2) = citrulline + nitric oxide + n NADP(+).,cofactor:Binds 1 FAD.,cofactor:Binds 1 FMN.,cofactor:Heme group.,cofactor:Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme.,enzyme regulation:Regulated by calcium/calmodulin. Aspirin inhibits expression and function of this enzyme and effects may be exerted at the level of translational/post-translational modification and directly on the catalytic activity.,function:Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions.,induction:By endotoxins and cytokines.,online information:Nitric oxide synthase entry,similarity:Belongs to the NOS family.,similarity:Contains 1 FAD-binding FR-type domain.,similarity:Contains 1 flavodoxin-like domain.,subunit:Homodimer. Binds SLC9A3R1.,tissue specificity:Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets.,
  • 纯化
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存与保存

1.保存：-20℃

2.有效期：1年

注意事项

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