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PP2A-B55-β Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM55230
复制产品信息
  • 种属：H，M，R
  • 用途：WB，IHC-P
规格:
50μl 100μl
单位:
支
单价:￥1500.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    PP2A-B55-β Rabbit Polyclonal Antibody
  • 别名
    PPP2R2B; Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform; PP2A subunit B isoform B55-beta; PP2A subunit B isoform PR55-beta; PP2A subunit B isoform R2-beta; PP2A subunit B isoform beta
  • 类别
    抗体产品
  • 基因名称
    PPP2R2B
  • 蛋白名称
    Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
  • Clonality
    Polyclonal
  • 推荐应用
    WB,IHC-P
  • 稀释度
    WB 1:500-2000, IHC-P 1:50-300
  • 反应种属
    Human,Mouse,Rat
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    5521
  • Human Swissprot No.
    Q00005
  • Mouse Gene ID
    72930
  • Mouse Swissprot No.
    Q6ZWR4
  • Rat Gene ID
    60660
  • Rat Swissprot No.
    P36877
  • 免疫原
    Synthesized peptide derived from PP2A-B55-β . at AA range: 90-170
  • 特异性
    PP2A-B55-β Polyclonal Antibody detects endogenous levels of PP2A-B55-β protein.
  • 预测分子量
    51kDa
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    protein phosphatase 2 regulatory subunit Bbeta(PPP2R2B) Homo sapiens The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isofor
  • 组织表达
    Brain
  • 细胞定位
    [Isoform 1]: Cytoplasm . Cytoplasm, cytoskeleton . Membrane .; [Isoform 2]: Cytoplasm . Mitochondrion . Mitochondrion outer membrane . Under basal conditions, localizes to both cytosolic and mitochondrial compartments. Relocalizes from the cytosolic to the mitochondrial compartment during apoptosis. Its targeting to the outer mitochondrial membrane (OMM) involves an association with import receptors of the TOM complex and is required to promote proapoptotic activity (By similarity). .
  • 信号通路
    Akt_PKB;Tight junction
  • 功能
    disease:Defects in PPP2R2B are the cause of spinocerebellar ataxia type 12 (SCA12) [MIM:604326]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA12 is an autosomal dominant cerebellar ataxia (ADCA).,function:The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.,similarity:Belongs to the phosphatase 2A regulatory subunit B family.,similarity:Contains 7 WD repeats.,subunit:PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.,tissue specificity:Brain.,
  • 纯化
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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