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PP2A-B56-α Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM55231
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  • 种属：H，M，R
  • 用途：WB，IHC-P
规格:
50μl 100μl
单位:
支
单价:￥1500.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    PP2A-B56-α Rabbit Polyclonal Antibody
  • 别名
    PPP2R5A; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform; PP2A B subunit isoform B'-alpha; PP2A B subunit isoform B56-alpha; PP2A B subunit isoform PR61-alpha; PR61alpha; PP2A B subunit isoform R5-alpha
  • 类别
    抗体产品
  • 基因名称
    PPP2R5A
  • 蛋白名称
    Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
  • Clonality
    Polyclonal
  • 推荐应用
    WB,IHC-P
  • 稀释度
    WB 1:500-2000, IHC-P 1:50-300
  • 反应种属
    Human,Mouse,Rat
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    5525
  • Human Swissprot No.
    Q15172
  • Mouse Gene ID
    226849
  • Mouse Swissprot No.
    Q6PD03
  • 免疫原
    The antiserum was produced against synthesized peptide derived from human PPP2R5A. AA range:321-370
  • 特异性
    PP2A-B56-α Polyclonal Antibody detects endogenous levels of PP2A-B56-α protein.
  • 预测分子量
    57kDa
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B56 subfamily. Alternative transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010],
  • 组织表达
    Widely expressed with the highest expression in heart and skeletal muscle.
  • 细胞定位
    Cytoplasm . Nucleus . Chromosome, centromere . From mitotic prophase to metaphase, localizes at the inner centromere between a pair of sister kinetochores. Decreased expression at the onset of anaphase. .
  • 信号通路
    Oocyte meiosis;WNT;WNT-T CELL
  • 功能
    function:The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.,PTM:Phosphorylated on serine residues.,similarity:Belongs to the phosphatase 2A regulatory subunit B56 family.,subcellular location:From mitotic prophase to metaphase, localizes at the inner centromere between a pair of sister kinetochores. Decreased expression at the onset of anaphase.,subunit:PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGOL1.,tissue specificity:Widely expressed with the highest expression in heart and skeletal muscle.,
  • 纯化
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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