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Rabenosyn-5 Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM55339
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  • 种属：H，M
  • 用途：WB，ELISA，IHC-P
规格:
50μl 100μl
单位:
支
单价:￥1500.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    Rabenosyn-5 Rabbit Polyclonal Antibody
  • 别名
    ZFYVE20; Rabenosyn-5; 110 kDa protein; FYVE finger-containing Rab5 effector protein rabenosyn-5; Zinc finger FYVE domain-containing protein 20
  • 类别
    抗体产品
  • 基因名称
    ZFYVE20
  • 蛋白名称
    Rabenosyn-5
  • Clonality
    Polyclonal
  • 推荐应用
    WB,ELISA,IHC-P
  • 稀释度
    WB 1:500-2000, IHC-P 1:50-300, ELISA 2000-20000
  • 反应种属
    Human,Mouse
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    64145
  • Human Swissprot No.
    Q9H1K0
  • Mouse Gene ID
    78287
  • Mouse Swissprot No.
    Q80Y56
  • 免疫原
    The antiserum was produced against synthesized peptide derived from human ZFYVE20. AA range:145-194
  • 特异性
    Rabenosyn-5 Polyclonal Antibody detects endogenous levels of Rabenosyn-5 protein.
  • 预测分子量
    89kDa
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    This gene encodes a protein that belongs to the FYVE zinc finger family of proteins. The encoded protein interacts with Ras-related proteins that regulate membrane trafficking. A missense mutation in this gene is associated with a defect in the early endocytic pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014],
  • 组织表达
    Brain,Cervix carcinoma,Epithelium,Human salivary gland,
  • 细胞定位
    Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane ; Lipid-anchor. Enriched in endosomes that are in close proximity to clathrin-enriched regions at the cell surface. .
  • 信号通路
    Endocytosis
  • 功能
    function:Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3).,similarity:Contains 1 C2H2-type zinc finger.,similarity:Contains 1 FYVE-type zinc finger.,similarity:Contains 1 UIM (ubiquitin-interacting motif) repeat.,subunit:Interacts with EHD1, RAB4A, RAB5A, RAB22A, RAB24 and VPS45. Binds simultaneously to RAB4A and RAB5A in vitro. Interacts with RAB4A and RAB5A that has been activated by GTP binding.,
  • 纯化
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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