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VE-Cadherin Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM56159
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  • 种属：H，M，R
  • 用途：WB，ELISA，IHC-P，IF-P，IF-F，IF-ICC
规格:
50μl 100μl
单位:
支
单价:￥1500.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    VE-Cadherin Rabbit Polyclonal Antibody
  • 别名
    CDH5; Cadherin-5; 7B4 antigen; Vascular endothelial cadherin; VE-cadherin; CD144
  • 类别
    抗体产品
  • 基因名称
    CDH5
  • 蛋白名称
    Cadherin-5
  • Clonality
    Polyclonal
  • 推荐应用
    IF-P,IF-F,IF-ICC,WB,IHC-P,ELISA
  • 稀释度
    IF-P/IF-F/IF-ICC 1:50-200, WB 1:500-2000, ELISA 1:10000-20000, IHC-P 1:50-300
  • 反应种属
    Human,Mouse,Rat
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    1003
  • Human Swissprot No.
    P33151
  • Mouse Gene ID
    12562
  • Mouse Swissprot No.
    P55284
  • 免疫原
    The antiserum was produced against synthesized peptide derived from the Internal region of human CDH5. AA range:391-440
  • 特异性
    VE-Cadherin Polyclonal Antibody detects endogenous levels of VE-Cadherin protein.
  • 预测分子量
    86kDa
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. [provided by RefSeq, Nov 2015],
  • 组织表达
    Endothelial tissues and brain.
  • 细胞定位
    Cell junction . Cell membrane ; Single-pass type I membrane protein . Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions. .
  • 信号通路
    Cell adhesion molecules (CAMs);Leukocyte transendothelial migration;
  • 功能
    function:Cadherins are calcium dependent cell adhesion proteins.,function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton.,similarity:Contains 5 cadherin domains.,subcellular location:Found at cell-cell boundaries and probably at cell-matrix boundaries.,tissue specificity:Endothelial tissues and brain.,
  • 纯化
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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