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Integrin αL Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM56859
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  • 种属：H，M，R
  • 用途：WB，ELISA
规格:
50μl 100μl
单位:
支
单价:￥1500.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    Integrin αL Rabbit Polyclonal Antibody
  • 别名
    ITGAL; CD11A; Integrin alpha-L; CD11 antigen-like family member A; Leukocyte adhesion glycoprotein LFA-1 alpha chain; LFA-1A; Leukocyte function-associated molecule 1 alpha chain; CD11a
  • 类别
    抗体产品
  • 基因名称
    ITGAL
  • 蛋白名称
    Integrin alpha-L
  • Clonality
    Polyclonal
  • 推荐应用
    WB,ELISA
  • 稀释度
    WB 1:500-1:2000, ELISA 1:10000.Not yet tested in other applications.
  • 反应种属
    Human,Rat,Mouse
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    3683
  • Human Swissprot No.
    P20701
  • Mouse Swissprot No.
    P24063
  • 免疫原
    The antiserum was produced against synthesized peptide derived from the Internal region of human ITGAL. AA range:171-220
  • 特异性
    Integrin αL Polyclonal Antibody detects endogenous levels of Integrin αL protein.
  • 预测分子量
    130kDa
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    integrin subunit alpha L(ITGAL) Homo sapiens ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
  • 组织表达
    Leukocytes
  • 细胞定位
    Cell membrane ; Single-pass type I membrane protein .
  • 信号通路
    Cell adhesion molecules (CAMs);Natural killer cell mediated cytotoxicity;Leukocyte transendothelial migration;Regulates Actin and Cytoskeleton;Viral myocarditis;
  • 功能
    domain:The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.,function:Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 1 VWFA domain.,similarity:Contains 7 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit. Alpha-L associates with beta-2.,tissue specificity:Leukocytes.,
  • 纯化
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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