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CD314 Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM57214
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  • 种属：H，M，R
  • 用途：ELISA，IHC-P，IF-P，IF-F，IF-ICC
规格:
50μl 100μl
单位:
支
单价:￥1500.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    CD314 Rabbit Polyclonal Antibody
  • 别名
    NKG2-D type II integral membrane protein (Killer cell lectin-like receptor subfamily K member 1;NK cell receptor D;NKG2-D-activating NK receptor;CD antigen CD314);D12S2489E;NKG2D
  • 类别
    抗体产品
  • 基因名称
    KLRK1
  • 蛋白名称
    NKG2-D type II integral membrane protein (Killer cell lectin-like receptor subfamily K member 1) (NK cell receptor D) (NKG2-D-activating NK receptor) (CD antigen CD314)
  • Clonality
    Polyclonal
  • 推荐应用
    IHC-P,IF-P,IF-F,IF-ICC,ELISA
  • 稀释度
    IHC-P 1:50-200, ELISA 1:10000-20000, IF-P/IF-F/IF-ICC 1:50-200
  • 反应种属
    Human,Rat,Mouse
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    100528032
  • Human Swissprot No.
    P26718
  • Mouse Gene ID
    27007
  • Mouse Swissprot No.
    O54709
  • 免疫原
    Synthetic peptide from human protein at AA range: 167-216
  • 特异性
    The antibody detects endogenous CD314
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of
  • 组织表达
    Expressed in natural killer (NK) cells, CD8(+) alpha-beta and gamma-delta T-cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Expressed in interferon-producing killer dendritic cells (IKDCs).
  • 细胞定位
    Cell membrane ; Single-pass type II membrane protein . Colocalized with HCST on the cell surface.
  • 信号通路
    Natural killer cell mediated cytotoxicity;
  • 功能
    alternative products:A number of isoforms are produced,function:Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes.,miscellaneous:Structurally distinct families of ligands for mouse and human NKG2D receptors have been characterized. They might be orthologs.,online information:NKG-2D,similarity:Contains 1 C-type lectin domain.,subunit:Homodimer. Interacts with DAP10. The interaction with DAP10 is required for NKG2D cell surface expression.,tissue specificity:Natural killer cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Also detected in gamma-delta cells and CD8+ alpha-beta T-cells. Expressed in interferon-producing killer dendritic cells (IKDCs).,
  • 纯化
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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