热搜词： 生化试剂 血清抗 细胞 pvdf膜 抗体

咨询热线

13564444959

产品中心

当前位置：首页 > 产品中心 > 抗体蛋白 > 一抗
产品中心
订货方式
订货电话：13564444959
订货时间：周一至周五
订货Q Q：79688691
订货邮件：79688691@qq.com
PLCD3 Rabbit Polyclonal Antibody  Cite:0    分享

货号： IM58266
复制产品信息
  • 种属：H，M
  • 用途：WB，IHC-P
规格:
50μl 100μl
单位:
支
单价:￥1500.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    PLCD3 Rabbit Polyclonal Antibody
  • 别名
    KIAA1964
  • 类别
    抗体产品
  • 基因名称
    PLCD3
  • 蛋白名称
    PLCD3
  • Clonality
    Polyclonal
  • 推荐应用
    WB,IHC-P
  • 稀释度
    WB 1:500-2000, IHC-P 1:50-300
  • 反应种属
    Human,Mouse
  • 浓度
    1 mg/ml
  • 存储缓冲液
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
  • Human Gene ID
    113026
  • Human Swissprot No.
    Q8N3E9
  • Mouse Gene ID
    72469
  • Mouse Swissprot No.
    Q8K2J0
  • 免疫原
    Synthesized peptide derived from human PLCD3 AA range: 501-551
  • 特异性
    This antibody detects endogenous levels of PLCD3 at Human/Mouse
  • 参考分子量
    87kDa
  • 宿主
    Rabbit
  • 同种型
    Rabbit,IgG
  • 背景介绍
    This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids. [provided by RefSeq, Jul 2008],
  • 组织表达
    Present in corneal epithelial cells (at protein level).
  • 细胞定位
    Membrane; Peripheral membrane protein. Cytoplasm. Cleavage furrow . Localizes at the cleavage furrow during cytokinesis. .
  • 功能
    catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.,cofactor:Binds 3 calcium ions per subunit. Two of the calcium ions are bound to the C2 domain.,domain:The C2 domain is a Ca(2+)-dependent membrane-targeting module.,domain:The PH domain mediates interaction with the surface membrane by binding to PIP2.,enzyme regulation:Strongly activated by phosphatidic acid. Inhibited by phosphatidylethanolamine (PtdEtn), phosphatidylcholine (PtdCho), sphingomyelin and phosphatidylserine (PtdSer).,function:Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow.,induction:Down-regulated by Ca(2+) and cAMP.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 PI-PLC X-box domain.,similarity:Contains 1 PI-PLC Y-box domain.,similarity:Contains 3 EF-hand domains.,subcellular location:Localizes at the cleavage furrow during cytokinesis.,tissue specificity:Present in corneal epithelial cells (at protein level).,
  • 纯化
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

备注：由于产品信息可能会有优化升级，请以实际收货标签信息为准。

产品推荐
<