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Smad2 (Phospho Thr8) /Smad3 (Thr8) (9U7) Rabbit Monoclonal Antibody  Cite:0    分享

货号： IM38750
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  • 种属：H，M，R
  • 用途：WB，IP，IF-ICC
规格:
50µl 100µl
单位:
支
单价:￥1600.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    Smad2 (Phospho Thr8) /Smad3 (Thr8) (9U7) Rabbit Monoclonal Antibody
  • 别名
    JV18; MADH2; MADR2; JV18-1; hMAD-2; hSMAD2
  • 类别
    抗体产品
  • Clonality
    Monoclonal
  • 推荐应用
    WB,IF-ICC,IP
  • 稀释度
    WB 1:1000, IF-ICC 1:50, IP 1:20-1:50
  • 反应种属
    Human,Mouse,Rat
  • 存储缓冲液
    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
  • Uniprot ID
    Q15796,P84022
  • Gene ID
    4087,4088
  • 免疫原
    A synthetic phosphopeptide corresponding to residues surrounding Thr8 of human Smad2
  • 参考分子量
    58,62kDa
  • 预测分子量
    52,48kDa
  • 宿主
    Rabbit
  • 同种型
    IgG
  • 背景介绍
    The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
  • 纯化
    Affinity Purification
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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