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Caveolin-2 (19D19) Rabbit Monoclonal Antibody  Cite:0    分享

货号： IM34117
复制产品信息
  • 种属：H，M，R
  • 用途：WB，IF-ICC
规格:
50µl 100µl
单位:
支
单价:￥1600.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    Caveolin-2 (19D19) Rabbit Monoclonal Antibody
  • 别名
    CAV2; Caveolae protein 20 Kd; Caveolin 2; Caveolin 2 isoform a and b; Caveolin-2;
  • 类别
    抗体产品
  • 基因名称
    CAV2
  • Clonality
    Monoclonal
  • 推荐应用
    WB,IF-ICC
  • 稀释度
    WB 1:1000-1:5000, IF-ICC 1:50
  • 反应种属
    Human,Mouse,Rat
  • 存储缓冲液
    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
  • Human Gene ID
    858
  • Human Swissprot No.
    P51636
  • 免疫原
    A synthetic peptide of human Caveolin-2
  • 参考分子量
    18kDa
  • 预测分子量
    18kDa
  • 宿主
    Rabbit
  • 同种型
    IgG
  • 组织表达
    Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts
  • 细胞定位
    Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27-phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments.
  • 功能
    May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).
  • 纯化
    Affinity-chromatography
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。

 

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