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Caspase-3 (16X19) Rabbit Monoclonal Antibody  Cite:0    分享

货号： IM34151
复制产品信息
  • 种属：H
  • 用途：WB，FCM，IP，IHC-P，IF-P，IF-ICC
规格:
50µl 100µl
单位:
支
单价:￥1600.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    Caspase-3 (16X19) Rabbit Monoclonal Antibody
  • 别名
    CASP3; Caspase-3; APOPAIN; CPP32; CPP32B; SCA-1; Caspase3
  • 类别
    抗体产品
  • 基因名称
    CASP3
  • 蛋白名称
    CPP32
  • Clonality
    Monoclonal
  • 推荐应用
    WB,IHC-P,IF-P,IF-ICC,FCM,IP
  • 稀释度
    WB 1:1000-1:5000, IHC-P/IF-P 1:20-1:100, IF-ICC 1:200-1:500, FCM 1:200-1:500, IP 1:20
  • 反应种属
    Human
  • 存储缓冲液
    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
  • Human Gene ID
    836
  • Human Swissprot No.
    P42574
  • 免疫原
    A synthetic peptide of human Caspase-3
  • 参考分子量
    32,17kDa
  • 预测分子量
    32kDa
  • 宿主
    Rabbit
  • 同种型
    IgG
  • 组织表达
    Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system
  • 细胞定位
    Cytoplasm
  • 功能
    Involved in the activation cascade of caspases responsible for apoptosis execution (PubMed:7596430). At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216- Asp-|-Gly-217' bond (PubMed:7774019). Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix- loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9 (PubMed:7596430). Involved in the cleavage of huntingtin (PubMed:8696339). Triggers cell adhesion in sympathetic neurons through RET cleavage (PubMed:21357690). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress (PubMed:23152800). Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface (PubMed:23845944, PubMed:33725486).
  • 纯化
    Affinity-chromatography
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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