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PP2A alpha (Phospho Y307) (13B6) Rabbit Monoclonal Antibody  Cite:0    分享

货号： IM34157
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  • 种属：H，M，R
  • 用途：WB，IP，IHC-P，IF-P，IF-F，IF-ICC，IHC-F
规格:
50µl 100µl
单位:
支
单价:￥1600.00
产品简介
储存与保存
注意事项
产品简介
  • 产品名称
    PP2A alpha (Phospho Y307) (13B6) Rabbit Monoclonal Antibody
  • 别名
    eplication protein C; PP2A-alpha; Replication protein C; RP-C; PPP2CA; MGC786
  • 类别
    抗体产品
  • 基因名称
    PPP2CA
  • Clonality
    Monoclonal
  • 推荐应用
    WB,IHC-P,IHC-F,IF-ICC,IF-P,IF-F,IP
  • 稀释度
    WB 1:1000-1:2000,IHC-P/IHC-F 1:100-1:200,IF-ICC 1:50-1:200,IF-P/IF-F 1:50-1:200,IP 1:20-1:50
  • 反应种属
    Human,Mouse,Rat
  • 存储缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Human Gene ID
    5515
  • Human Swissprot No.
    P67775
  • 参考分子量
    35kDa
  • 预测分子量
    36kDa
  • 宿主
    Rabbit
  • 同种型
    IgG
  • 细胞定位
    Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres (PubMed:16541025). During mitosis, also found at spindle poles (PubMed:16541025). Centromeric localization requires the presence of SGO2 (By similarity) {ECO:0000250|UniProtKB:P63330, ECO:0000269|PubMed:16541025}
  • 功能
    PP2A is the major phosphatase for microtubule-associated proteins (MAPs) (PubMed:22613722). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase (PubMed:22613722). Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53 (PubMed:17245430). Activates RAF1 by dephosphorylating it at 'Ser-259' (PubMed:10801873). Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758). Mediates dephosphorylation of MYC; promoting its ubiquitin-mediated proteolysis: interaction with AMBRA1 enhances interaction between PPP2CA and MYC (PubMed:25438055). Mediates dephosphorylation of FOXO3; promoting its stabilization: interaction with AMBRA1 enhances interaction between PPP2CA and FOXO3 (PubMed:30513302).
  • 纯度
    Affinity-chromatography
储存与保存

1.保存：-20℃，Avoid freeze/thaw cycles

2.有效期：1年

注意事项

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

3. 实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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