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TRIM25 (1S16) Rabbit Monoclonal Antibody  Cite:0    分享

货号： IM35528
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  • 种属：H，M，R
  • 用途：WB，FCM，IP，IHC-P，IF-P，IF-ICC
规格:
50µl 100µl
单位:
支
单价:￥1200.00
产品简介
储存与保存
注意事项
产品简介
  • 产品货号
    IM35528
  • 纯度
    Affinity-chromatography
  • 别名
    EFP; RNF147; TRI25; TRIM 25; Trim25; Z147; ZNF147;
  • 产品名称
    TRIM25 (1S16) Rabbit Monoclonal Antibody
  • 类别
    抗体产品
  • 基因名称
    TRIM25
  • 蛋白名称
    EFP {ECO:0000303|PubMed:8248217}, RNF147
  • Clonality
    Monoclonal
  • 推荐应用
    WB,IHC-P,IF-P,IF-ICC,FCM,IP
  • 反应种属
    Human,Mouse,Rat
  • 存储缓冲液
    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
  • Human Gene ID
    7706
  • Human Swissprot No.
    Q14258
  • 免疫原
    A synthetic peptide of human TRIM25
  • 稀释度
    WB 1:1000-1:10000, IHC-P/IF-P 1:100-1:200, IF-ICC 1:200-1:1000, FCM 1:50-1:100, IP 1:20-1:100
  • 参考分子量
    71kDa
  • 预测分子量
    71kDa
  • 宿主
    Rabbit
  • 同种型
    IgG
  • 注意事项
    TRIM25 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
  • 组织表达
    Expressed in breast tumors (at protein level). Ubiquitous.
  • 细胞定位
    Cytoplasm. Cytoplasm, Stress granule. Nucleus {ECO:0000250|UniProtKB:Q61510}
  • 功能
    Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase (PubMed:16352599). Involved in innate immune defense against viruses by mediating ubiquitination of DDX58 and IFIH1 (PubMed:17392790, PubMed:30193849, PubMed:33849980). Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region and may play a role in signal transduction that leads to the production of interferons in response to viral infection (PubMed:17392790, PubMed:23950712). Mediates 'Lys-63'-linked polyubiquitination of IFIH1 (PubMed:30193849). Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway (PubMed:16352599, PubMed:17069755). Mediates estrogen action in various target organs (PubMed:22452784). Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784). Plays a role in promoting the restart of stalled replication forks via interaction with the KHDC3L-OOEP scaffold and subsequent ubiquitination of BLM, resulting in the recruitment and retainment of BLM at DNA replication forks (By similarity).
储存与保存

1.保存：-20℃
2.有效期：1年

注意事项

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。

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