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LRP6 (Phospho S1490) (10R3) Rabbit Monoclonal Antibody  Cite:0    分享

货号： IM37062
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  • 种属：H
  • 用途：WB
规格:
50µl 100µl
单位:
支
单价:￥1200.00
产品简介
储存与保存
注意事项
产品简介
  • 产品货号
    IM37062
  • 别名
    Low-density lipoprotein receptor-related protein 7
  • 产品名称
    LRP6 (Phospho S1490) (10R3) Rabbit Monoclonal Antibody
  • 类别
    抗体产品
  • 基因名称
    LRP6
  • Clonality
    Monoclonal
  • 推荐应用
    WB
  • 反应种属
    Human
  • 存储缓冲液
    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
  • Human Gene ID
    4040
  • Human Swissprot No.
    O75581
  • 免疫原
    A synthetic phosphopeptide corresponding to residues surrounding Ser1490 of human LRP6
  • 稀释度
    WB 1:1000-1:5000
  • 参考分子量
    180kDa
  • 预测分子量
    180kDa
  • 宿主
    Rabbit
  • 同种型
    IgG
  • 注意事项
    Phospho-LRP6 (S1490) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
  • 组织表达
    Widely coexpressed with LRP5 during embryogenesis and in adult tissues
  • 细胞定位
    Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Membrane raft. Note=On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palmitoylation Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmitoylation. On Wnt signaling, phosphorylated, aggregates and colocalizes with AXIN1 and GSK3B at the plasma membrane in LRP6- signalsomes. Chaperoned to the plasma membrane by MESD (By similarity)
  • 功能
    Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).
  • 纯度
    Affinity-chromatography
储存与保存

Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles.

注意事项

1.我司生产的生化试剂如无特殊标注，基本为非无菌包装，若用于细胞实验，请提前做好预处理。需低温保存的产品，一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

2.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

3.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

4.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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