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ErbB2 (Phospho Y1221 + Y1222) (11Z13) Rabbit Monoclonal Antibody  Cite:0    分享

货号： IM37063
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  • 种属：H
  • 用途：WB
规格:
50µl 100µl
单位:
支
单价:￥1200.00
产品简介
储存与保存
注意事项
产品简介
  • 产品货号
    IM37063
  • 别名
    CD340; CerbB2; Erb b2 receptor tyrosine kinase 2; ERBB2; HER2; Herstatin; Human epidermal growth factor receptor 2; MLN19; NEU; NGL; Proto-oncogene Neu; Receptor tyrosine-protein kinase erbB-2; Tyrosine kinase type cell surface receptor HER2; V erb b2 avian erythroblastic leukemia viral oncogene homolog 2; V erb b2 avian erythroblastic leukemia viral oncoprotein 2
  • 产品名称
    ErbB2 (Phospho Y1221 + Y1222) (11Z13) Rabbit Monoclonal Antibody
  • 类别
    抗体产品
  • 基因名称
    ERBB2
  • 蛋白名称
    HER2, MLN19, NEU, NGL
  • Clonality
    Monoclonal
  • 推荐应用
    WB
  • 反应种属
    Human
  • 存储缓冲液
    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
  • Human Gene ID
    2064
  • Human Swissprot No.
    P04626
  • 免疫原
    A synthetic phosphopeptide corresponding to residues surrounding Tyr1221/Tyr1222 of human ErbB 2
  • 稀释度
    WB 1:1000-1:5000
  • 参考分子量
    185kDa
  • 预测分子量
    138kDa
  • 宿主
    Rabbit
  • 同种型
    IgG
  • 注意事项
    Phospho-ErbB2(Y1221 + Y1222) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
  • 组织表达
    Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.
  • 细胞定位
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein Early endosome. Cytoplasm, perinuclear region. Nucleus. Note=Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1. Also detected in VPS35-positive endosome-to-TGN retrograde vesicles (PubMed:31138794). [Isoform 3]: Cytoplasm. Nucleus.
  • 功能
    Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
  • 纯度
    Affinity-chromatography
储存与保存

Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles.

注意事项

1.我司生产的生化试剂如无特殊标注，基本为非无菌包装，若用于细胞实验，请提前做好预处理。需低温保存的产品，一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

2.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

3.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

4.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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