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Rb (Phospho S780) (9L11) Rabbit Monoclonal Antibody  Cite:0    分享

货号： IM37064
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  • 种属：H
  • 用途：WB，IHC-P，IF-P
规格:
50µl 100µl
单位:
支
单价:￥1200.00
产品简介
储存与保存
注意事项
产品简介
  • 产品货号
    IM37064
  • 别名
    OSRC; Osteosarcoma; P105RB; PP105; pp110; PPP1R130;Prepro retinoblastoma associated protein; RB transcriptional corepressor 1; RB1; Retinoblastoma 1; Retinoblastoma suspectibility protein.
  • 产品名称
    Rb (Phospho S780) (9L11) Rabbit Monoclonal Antibody
  • 类别
    抗体产品
  • 基因名称
    RB1
  • Clonality
    Monoclonal
  • 推荐应用
    WB,IHC-P,IF-P
  • 反应种属
    Human
  • 存储缓冲液
    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
  • Human Gene ID
    5925
  • Human Swissprot No.
    P06400
  • 免疫原
    A synthetic phosphopeptide corresponding to residues surrounding Ser780 of human Rb
  • 稀释度
    WB 1:1000-1:5000, IHC-P/IF-P 1:100
  • 参考分子量
    110kDa
  • 预测分子量
    106kDa
  • 宿主
    Rabbit
  • 同种型
    IgG
  • 注意事项
    Phospho-Rb (S780) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
  • 组织表达
    Expressed in the retina. Expressed in foreskin keratinocytes (at protein level) (PubMed:20940255)
  • 细胞定位
    Nucleus. Note=During keratinocyte differentiation, acetylation by KAT2B/PCAF is required for nuclear localization.
  • 功能
    Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin- modifying enzymes that actively repress transcription (PubMed:10499802). Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase (PubMed:10499802). RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C (PubMed:15084261). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1- dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity).
  • 纯度
    Affinity-chromatography
储存与保存

Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles.

注意事项

1.我司生产的生化试剂如无特殊标注，基本为非无菌包装，若用于细胞实验，请提前做好预处理。需低温保存的产品，一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

2.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

3.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

4.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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