热搜词： 生化试剂 血清抗 细胞 pvdf膜 抗体

咨询热线

13564444959

产品中心

当前位置：首页 > 产品中心 > 抗体蛋白 > 一抗
产品中心
订货方式
订货电话：13564444959
订货时间：周一至周五
订货Q Q：79688691
订货邮件：79688691@qq.com
HRPT2 / CDC73 (19W5) Rabbit Monoclonal Antibody  Cite:0    分享

货号： IM37074
复制产品信息
  • 种属：H，M，R
  • 用途：WB，FCM，IHC-P
规格:
50µl 100µl
单位:
支
单价:￥1600.00
产品简介
储存与保存
注意事项
产品简介
  • 产品货号
    IM37074
  • 别名
    Cdc73; FIHP; HPTJT; HRPT1; HRPT2; Hyperparathyroidism 2; HYX
  • 产品名称
    HRPT2 / CDC73 (19W5) Rabbit Monoclonal Antibody
  • 类别
    抗体产品
  • 基因名称
    CDC73
  • 蛋白名称
    C1orf28, HRPT2
  • Clonality
    Monoclonal
  • 推荐应用
    WB,IHC-P,FCM
  • 反应种属
    Human,Mouse,Rat
  • 存储缓冲液
    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
  • Human Gene ID
    79577
  • Human Swissprot No.
    Q6P1J9
  • 免疫原
    A synthetic peptide of human HRPT2
  • 稀释度
    WB 1:1000, IHC-P/IF-P 1:200-1:1000, FCM 1:200-1:500
  • 参考分子量
    61kDa
  • 预测分子量
    61kDa
  • 宿主
    Rabbit
  • 同种型
    IgG
  • 注意事项
    HRPT2 / CDC73 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
  • 组织表达
    Found in adrenal and parathyroid glands, kidney and heart.
  • 细胞定位
    Nucleus
  • 功能
    Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling. Involved in polyadenylation of mRNA precursors.
  • 纯度
    Affinity-chromatography
储存与保存

Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles.

注意事项

1.我司生产的生化试剂如无特殊标注，基本为非无菌包装，若用于细胞实验，请提前做好预处理。需低温保存的产品，一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

2.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

3.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

4.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

备注：由于产品信息可能会有优化升级，请以实际收货标签信息为准。

产品推荐
<