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CD223 (17Z3) Rabbit Monoclonal Antibody  Cite:0    分享

货号： IM37078
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  • 种属：H
  • 用途：IHC-P，IF-P
规格:
50µl 100µl
单位:
支
单价:￥1600.00
产品简介
储存与保存
注意事项
产品简介
  • 产品货号
    IM37078
  • 别名
    CD223; Lag3; Lymphocyte activating 3; Protein FDC
  • 产品名称
    CD223 (17Z3) Rabbit Monoclonal Antibody
  • 类别
    抗体产品
  • 基因名称
    LAG3
  • 蛋白名称
    FDC
  • Clonality
    Monoclonal
  • 推荐应用
    IHC-P,IF-P
  • 反应种属
    Human
  • 存储缓冲液
    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
  • Human Gene ID
    3902
  • Human Swissprot No.
    P18627
  • 免疫原
    A synthetic peptide of human Lymphocyte Activation Gene 3
  • 稀释度
    IHC-P/IF-P 1:200-1:1000
  • 预测分子量
    58kDa
  • 宿主
    Rabbit
  • 同种型
    IgG
  • 注意事项
    CD223 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
  • 组织表达
    Primarily expressed in activated T-cells and a subset of natural killer (NK) cells.
  • 细胞定位
    [Lymphocyte activation gene 3 protein]: Cell membrane; Single-pass type I membrane protein
  • 功能
    Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells (PubMed:7805750, PubMed:8647185, PubMed:20421648). Delivers inhibitory signals upon binding to ligands, such as FGL1 (By similarity). FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function (By similarity). Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1 (By similarity). Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells (PubMed:7805750, PubMed:8647185, PubMed:20421648). Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function (By similarity). Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation (By similarity). Binds MHC class II (MHC-II); the precise role of MHC-II-binding is however unclear (PubMed:8647185).
  • 纯度
    Affinity-chromatography
储存与保存

Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles.

注意事项

1.我司生产的生化试剂如无特殊标注，基本为非无菌包装，若用于细胞实验，请提前做好预处理。需低温保存的产品，一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

2.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 

3.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 

4.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。 

 

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